TY - JOUR
T1 - Circulating 25-hydroxyvitamin D and risk of kidney cancer
T2 - Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
AU - Gallicchio, Lisa
AU - Moore, Lee E.
AU - Stevens, Victoria L.
AU - Ahn, Jiyoung
AU - Albanes, Demetrius
AU - Hartmuller, Virginia
AU - Setiawan, V. Wendy
AU - Helzlsouer, Kathy J.
AU - Yang, Gong
AU - Xiang, Yong Bing
AU - Shu, Xiao Ou
AU - Snyder, Kirk
AU - Weinstein, Stephanie J.
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne
AU - Zheng, Wei
AU - Cai, Qiuyin
AU - Campbell, David S.
AU - Chen, Yu
AU - Chow, Wong Ho
AU - Horst, Ronald L.
AU - Kolonel, Laurence N.
AU - McCullough, Marjorie L.
AU - Purdue, Mark P.
AU - Koenig, Karen L.
PY - 2010
Y1 - 2010
N2 - Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12,0.85) with 25(OH)D concentrations of ≥75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.
AB - Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12,0.85) with 25(OH)D concentrations of ≥75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.
KW - Case-control studies
KW - Cohort studies
KW - Kidney neoplasms
KW - Prospective studies
KW - Vitamin D
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U2 - 10.1093/aje/kwq115
DO - 10.1093/aje/kwq115
M3 - Article
C2 - 20562187
AN - SCOPUS:78549258326
SN - 0002-9262
VL - 172
SP - 47
EP - 57
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 1
ER -