Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Lisa Gallicchio, Lee E. Moore, Victoria L. Stevens, Jiyoung Ahn, Demetrius Albanes, Virginia Hartmuller, V. Wendy Setiawan, Kathy J. Helzlsouer, Gong Yang, Yong Bing Xiang, Xiao Ou Shu, Kirk Snyder, Stephanie J. Weinstein, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Qiuyin Cai, David S. Campbell, Yu Chen, Wong Ho ChowRonald L. Horst, Laurence N. Kolonel, Marjorie L. McCullough, Mark P. Purdue, Karen L. Koenig

Research output: Contribution to journalArticlepeer-review

Abstract

Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12,0.85) with 25(OH)D concentrations of ≥75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.

Original languageEnglish (US)
Pages (from-to)47-57
Number of pages11
JournalAmerican Journal of Epidemiology
Volume172
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Case-control studies
  • Cohort studies
  • Kidney neoplasms
  • Prospective studies
  • Vitamin D

ASJC Scopus subject areas

  • Epidemiology

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