Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse

Shoshana Yakar; Patricia Pennisi; Hong Zhao; Yang Zhang; Derek LeRoith; Meyts De Meyts

Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse

Shoshana Yakar, Patricia Pennisi, Hong Zhao, Yang Zhang, Derek LeRoith, Meyts De Meyts

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.

Original language	English (US)
Pages (from-to)	3-18
Number of pages	16
Journal	Novartis Foundation symposium
Volume	262
State	Published - 2004

ASJC Scopus subject areas

General Medicine

Cite this

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abstract = "Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.",

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AU - Zhao, Hong

AU - Zhang, Yang

AU - LeRoith, Derek

AU - De Meyts, Meyts

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AB - Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.

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Circulating IGF-1 and its role in cancer: Lessons from the IGF-1 gene deletion (LID) mouse

Abstract

ASJC Scopus subject areas

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