Abstract
Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.
| Original language | English (US) |
|---|---|
| Title of host publication | Biology of IGF-1 |
| Subtitle of host publication | Its Interaction with Insulin in Health and Malignant States |
| Publisher | Wiley |
| Pages | 3-17 |
| Number of pages | 15 |
| Volume | 262 |
| ISBN (Electronic) | 9780470869970 |
| ISBN (Print) | 9780470869987 |
| DOIs | |
| State | Published - Oct 7 2008 |
Keywords
- Acid labile subunit (ALS) null gene
- Blocking peptides and blocking antibodies
- Circulating IGF-1 levels
- IGF binding proteins (IGFBPs)
- IGF-1R tyrosine kinase inhibitors
- IGFs and cancer
- Insulin-like growth factors (IGFs)
- LID mice
- Serum IGF-1 and cancer
ASJC Scopus subject areas
- General Medicine