Circulating IGF-1 and Its Role in Cancer: Lessons from the IGF-1 Gene Deletion (LID) Mouse: Discussion

Shoshana Yakar, Patricia Pennisi, Hong Zhao, Yang Zhang, Derek LeRoith

Research output: Chapter in Book/Report/Conference proceedingChapter


Recent epidemiological studies have suggested a statistical connection between serum IGF-1 levels in the upper quartile of the normal range and the relative risk of developing certain cancers. Our studies have focused on mouse models where circulating IGF-1 levels are reduced, while tissue expression of IGF-1 is normal. These mice show a lower risk for the development of colon and breast cancers and metastases when compared with control mice, and lend support to the hypothesis that circulating IGF-1 may be linked to cancer cell growth.

Original languageEnglish (US)
Title of host publicationBiology of IGF-1
Subtitle of host publicationIts Interaction with Insulin in Health and Malignant States
Number of pages15
ISBN (Electronic)9780470869970
ISBN (Print)9780470869987
StatePublished - Oct 7 2008


  • Acid labile subunit (ALS) null gene
  • Blocking peptides and blocking antibodies
  • Circulating IGF-1 levels
  • IGF binding proteins (IGFBPs)
  • IGF-1R tyrosine kinase inhibitors
  • IGFs and cancer
  • Insulin-like growth factors (IGFs)
  • LID mice
  • Serum IGF-1 and cancer

ASJC Scopus subject areas

  • General Medicine


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