TY - JOUR
T1 - Circulating IGF-axis protein levels and their relation with levels of plasma adipocytokines and macronutrient consumption in women
AU - Beasley, Jeannette M.
AU - Wedick, Nicole M.
AU - Rajpathak, Swapnil N.
AU - Xue, Xiaonan
AU - Holmes, Michelle D.
AU - Gunter, Marc J.
AU - Wylie-Rosett, Judith
AU - Rohan, Thomas E.
AU - Pollak, Michael
AU - Kaplan, Robert C.
AU - Hu, Frank B.
AU - Sun, Qi
AU - Strickler, Howard D.
N1 - Funding Information:
This work was funded by R00AG035002, 5R01DK080792, R00HL098459, and 1R01AG031890. The Nurses' Health Study is supported by CA87969, DK58845, and DK58785.
PY - 2014/8
Y1 - 2014/8
N2 - Objective: Circulating free insulin-like growth factor (IGF)-I and its binding proteins, most notably, IGFBP-1 and IGFBP-2, have been prospectively associated with incident type 2 diabetes in women. However, little is known regarding the factors that may influence these IGF-axis protein levels. The aim is to study the relation of IGF-axis protein levels with adipcytokines, macronutrient consumption, and other factors related to diabetes. Design: Fasting plasma from 558 controls enrolled in a nested case-control study within the Nurses' Health Study of incident type 2 diabetes in women was tested for: IGF-axis proteins (free and total IGF-I, IGFBP-1, IGFBP-2, IGFBP-3), adipocytokines (leptin, adiponectin, resistin), soluble leptin receptor (sOB-R), inflammatory factors (IL-18 and C-reactive protein (CRP)), insulin, and glycated hemoglobin (HbA1C). Results: In multivariate models, each 1% increase in sOB-R (mean 34.9. ng/mL, standard deviation (SD) ±. 11.3) was associated with - 0.20% total IGF-I (P. = 0.0003) and - 0.42% free IGF-I (P. = 0.002), as well as 0.73% higher IGFBP-1 (P. <. 0.0001) and 0.27% IGFBP-2 (P. = 0.003). For example, a one SD change from the mean sOB-R level was associated with 11% lower free IGF-I. Insulin levels (mean 6.8. μU/mL. ±. 5.3) were inversely and adiponectin (mean 18.3. μg/mL. ±. 7.4) positively associated with IGFBP-1 and IGFBP-2 (all P. <. 0.01). Consumption of dairy protein, monounsaturated fats, and saturated fats, was also correlated with IGF-axis protein levels (all P. <. 0.05). Conclusions: Several molecular factors and macronutrients were independently associated with plasma IGF-axis protein levels. Which of these, if any, reflect biologic relationships that can be intervened upon to influence IGF-axis protein concentrations warrants further investigation.
AB - Objective: Circulating free insulin-like growth factor (IGF)-I and its binding proteins, most notably, IGFBP-1 and IGFBP-2, have been prospectively associated with incident type 2 diabetes in women. However, little is known regarding the factors that may influence these IGF-axis protein levels. The aim is to study the relation of IGF-axis protein levels with adipcytokines, macronutrient consumption, and other factors related to diabetes. Design: Fasting plasma from 558 controls enrolled in a nested case-control study within the Nurses' Health Study of incident type 2 diabetes in women was tested for: IGF-axis proteins (free and total IGF-I, IGFBP-1, IGFBP-2, IGFBP-3), adipocytokines (leptin, adiponectin, resistin), soluble leptin receptor (sOB-R), inflammatory factors (IL-18 and C-reactive protein (CRP)), insulin, and glycated hemoglobin (HbA1C). Results: In multivariate models, each 1% increase in sOB-R (mean 34.9. ng/mL, standard deviation (SD) ±. 11.3) was associated with - 0.20% total IGF-I (P. = 0.0003) and - 0.42% free IGF-I (P. = 0.002), as well as 0.73% higher IGFBP-1 (P. <. 0.0001) and 0.27% IGFBP-2 (P. = 0.003). For example, a one SD change from the mean sOB-R level was associated with 11% lower free IGF-I. Insulin levels (mean 6.8. μU/mL. ±. 5.3) were inversely and adiponectin (mean 18.3. μg/mL. ±. 7.4) positively associated with IGFBP-1 and IGFBP-2 (all P. <. 0.01). Consumption of dairy protein, monounsaturated fats, and saturated fats, was also correlated with IGF-axis protein levels (all P. <. 0.05). Conclusions: Several molecular factors and macronutrients were independently associated with plasma IGF-axis protein levels. Which of these, if any, reflect biologic relationships that can be intervened upon to influence IGF-axis protein concentrations warrants further investigation.
KW - Adipocytokines
KW - Free IGF-I
KW - IGF-I
KW - IGFBP-1
KW - IGFBP-2
KW - IGFBP-3
KW - Macronutrients
UR - http://www.scopus.com/inward/record.url?scp=84903735288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903735288&partnerID=8YFLogxK
U2 - 10.1016/j.ghir.2014.04.006
DO - 10.1016/j.ghir.2014.04.006
M3 - Article
C2 - 24888819
AN - SCOPUS:84903735288
SN - 1096-6374
VL - 24
SP - 142
EP - 149
JO - Growth Hormone and IGF Research
JF - Growth Hormone and IGF Research
IS - 4
ER -