Circulating IGF-axis protein levels and their relation with levels of plasma adipocytokines and macronutrient consumption in women

Jeannette M. Beasley, Nicole M. Wedick, Swapnil N. Rajpathak, Xiaonan Xue, Michelle D. Holmes, Marc J. Gunter, Judith Wylie-Rosett, Thomas E. Rohan, Michael Pollak, Robert C. Kaplan, Frank B. Hu, Qi Sun, Howard D. Strickler

Research output: Contribution to journalArticlepeer-review


Objective: Circulating free insulin-like growth factor (IGF)-I and its binding proteins, most notably, IGFBP-1 and IGFBP-2, have been prospectively associated with incident type 2 diabetes in women. However, little is known regarding the factors that may influence these IGF-axis protein levels. The aim is to study the relation of IGF-axis protein levels with adipcytokines, macronutrient consumption, and other factors related to diabetes. Design: Fasting plasma from 558 controls enrolled in a nested case-control study within the Nurses' Health Study of incident type 2 diabetes in women was tested for: IGF-axis proteins (free and total IGF-I, IGFBP-1, IGFBP-2, IGFBP-3), adipocytokines (leptin, adiponectin, resistin), soluble leptin receptor (sOB-R), inflammatory factors (IL-18 and C-reactive protein (CRP)), insulin, and glycated hemoglobin (HbA1C). Results: In multivariate models, each 1% increase in sOB-R (mean 34.9. ng/mL, standard deviation (SD) ±. 11.3) was associated with - 0.20% total IGF-I (P. = 0.0003) and - 0.42% free IGF-I (P. = 0.002), as well as 0.73% higher IGFBP-1 (P. <. 0.0001) and 0.27% IGFBP-2 (P. = 0.003). For example, a one SD change from the mean sOB-R level was associated with 11% lower free IGF-I. Insulin levels (mean 6.8. μU/mL. ±. 5.3) were inversely and adiponectin (mean 18.3. μg/mL. ±. 7.4) positively associated with IGFBP-1 and IGFBP-2 (all P. <. 0.01). Consumption of dairy protein, monounsaturated fats, and saturated fats, was also correlated with IGF-axis protein levels (all P. <. 0.05). Conclusions: Several molecular factors and macronutrients were independently associated with plasma IGF-axis protein levels. Which of these, if any, reflect biologic relationships that can be intervened upon to influence IGF-axis protein concentrations warrants further investigation.

Original languageEnglish (US)
Pages (from-to)142-149
Number of pages8
JournalGrowth Hormone and IGF Research
Issue number4
StatePublished - Aug 2014


  • Adipocytokines
  • Free IGF-I
  • IGF-I
  • IGFBP-1
  • IGFBP-2
  • IGFBP-3
  • Macronutrients

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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