Classical and emerging regulatory mechanisms of cytokinesis in animal cells

Vikash Verma, Alex Mogilner, Thomas J. Maresca

Research output: Contribution to journalReview article

Abstract

The primary goal of cytokinesis is to produce two daughter cells, each having a full set of chromosomes. To achieve this, cells assemble a dynamic structure between segregated sister chromatids called the contractile ring, which is made up of filamentous actin, myosin-II, and other regulatory proteins. Constriction of the actomyosin ring generates a cleavage furrow that divides the cytoplasm to produce two daughter cells. Decades of research have identified key regulators and underlying molecular mechanisms; however, many fundamental questions remain unanswered and are still being actively investigated. This review summarizes the key findings, computational modeling, and recent advances in understanding of the molecular mechanisms that control the formation of the cleavage furrow and cytokinesis.

Original languageEnglish (US)
Article number55
JournalBiology
Volume8
Issue number3
DOIs
StatePublished - Sep 2019

Keywords

  • Aurora B kinase
  • Centralspindlin complex
  • Cortical excitability
  • Cytokinesis
  • ECT2
  • Microtubules
  • Polo kinase
  • RhoA
  • RhoA and actin waves

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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