(Chemical Equation Presented) We describe an efficient protocol to effect multisite conjugation reactions to oligomers on solid-phase support. Sequence-specific N-substituted glycine "oligopeptoids" were utilized as substrates for azide-alkyne cycloaddition reactions. Diverse groups, including nucleobases and fluorophores, were conjugated at up to six positions on peptoid side chains with yields ranging from 88 to 96%. This strategy will be broadly applicable for generating polyvalent displays on peptides and other scaffolds, allowing precise control of spacing between the displayed groups.
|Original language||English (US)|
|Number of pages||4|
|State||Published - May 12 2005|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry