Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India

Anupkumar R. Anvikar, Anna Maria van Eijk, Asha Shah, Kamlesh J. Upadhyay, Steven A. Sullivan, Ankita J. Patel, Jaykumar M. Joshi, Suchi Tyagi, Ranvir Singh, Jane M. Carlton, Himanshu Gupta, Samuel C. Wassmer

Research output: Contribution to journalArticlepeer-review


The mounting evidence supporting the capacity of Plasmodium vivax to cause severe disease has prompted the need for a better characterization of the resulting clinical complications. India is making progress with reducing malaria, but epidemics of severe vivax malaria in Gujarat, one of the main contributors to the vivax malaria burden in the country, have been reported recently and may be the result of a decrease in transmission and immune development. Over a period of one year, we enrolled severe malaria patients admitted at the Civil Hospital in Ahmedabad, the largest city in Gujarat, to investigate the morbidity of severe vivax malaria compared to severe falciparum malaria. Patients were submitted to standard thorough clinical and laboratory investigations and only PCR-confirmed infections were selected for the present study. Severevivax malaria (30 patients) was more frequent than severe falciparum malaria (8 patients) in our setting, and it predominantly affected adults (median age 32 years, interquartile range 22.5 years). This suggests a potential age shift in anti-malarial immunity, likely to result from the recent decrease in transmission across India. The clinical presentation of severe vivax patients was in line with previous reports, with jaundice as the most common complication. Our findings further support the need for epidemiological studies combining clinical characterization of severe vivax malaria and serological evaluation of exposure markers to monitor the impact of elimination programmes.

Original languageEnglish (US)
Pages (from-to)730-738
Number of pages9
Issue number1
StatePublished - Jan 1 2020


  • Gujarat
  • India
  • Plasmodium vivax
  • Severe malaria
  • malaria elimination

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases


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