Clinical considerations for vascularized composite allotransplantation of the eye

Edward H. Davidson, Eric W. Wang, Jenny Y. Yu, Juan C. Fernandez-Miranda, Dawn J. Wang, Yang Li, Maxine Miller, Wesley N. Sivak, Debra Bourne, Hongkun Wang, Mario G. Solari, Joel S. Schuman, Kia M. Washington

    Research output: Contribution to journalArticle

    Abstract

    Vascularized composite allotransplantation represents a potential shift in approaches to reconstruction of complex defects resulting from congenital differences as well as trauma and other acquired pathology. Given the highly specialized function of the eye and its unique anatomical components, vascularized composite allotransplantation of the eye is an appealing method for restoration, replacement, and reconstruction of the nonfunctioning eye. Herein, we describe conventional treatments for eye restoration and their shortcomings as well as recent research and events that have brought eye transplantation closer to a potential clinical reality. In this article, we outline some potential considerations in patient selection, donor facial tissue procurement, eye tissue implantation, surgical procedure, and potential for functional outcomes.

    Original languageEnglish (US)
    Pages (from-to)1622-1628
    Number of pages7
    JournalJournal of Craniofacial Surgery
    Volume27
    Issue number7
    DOIs
    StatePublished - 2016

    Keywords

    • Composite tissue allotransplantation
    • Eye transplant
    • Face transplant
    • Reconstructive transplantation
    • Vascularised composite allotransplantation

    ASJC Scopus subject areas

    • Surgery
    • Otorhinolaryngology

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  • Cite this

    Davidson, E. H., Wang, E. W., Yu, J. Y., Fernandez-Miranda, J. C., Wang, D. J., Li, Y., Miller, M., Sivak, W. N., Bourne, D., Wang, H., Solari, M. G., Schuman, J. S., & Washington, K. M. (2016). Clinical considerations for vascularized composite allotransplantation of the eye. Journal of Craniofacial Surgery, 27(7), 1622-1628. https://doi.org/10.1097/SCS.0000000000002985