Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas

Mekka R. Garcia; Yang Feng; Varshini Vasudevaraja; Kristyn Galbraith; Jonathan Serrano; Cheddhi Thomas; Alireza Radmanesh; Eveline T. Hidalgo; David H. Harter; Jeffrey C. Allen; Sharon L. Gardner; Diana S. Osorio; Christopher M. William; David Zagzag; Daniel R. Boué; Matija Snuderl

doi:10.1093/jnen/nlac075

Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas

Mekka R. Garcia, Yang Feng, Varshini Vasudevaraja, Kristyn Galbraith, Jonathan Serrano, Cheddhi Thomas, Alireza Radmanesh, Eveline T. Hidalgo, David H. Harter, Jeffrey C. Allen, Sharon L. Gardner, Diana S. Osorio, Christopher M. William, David Zagzag, Daniel R. Boué, Matija Snuderl

Global Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1-82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.

Original language	English (US)
Pages (from-to)	865-872
Number of pages	8
Journal	Journal of Neuropathology and Experimental Neurology
Volume	81
Issue number	11
DOIs	https://doi.org/10.1093/jnen/nlac075
State	Published - Nov 1 2022

Keywords

Gliomas
H3-K27M
Molecular
Neuro-oncology
Spinal cord
Tumors

ASJC Scopus subject areas

General Medicine

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10.1093/jnen/nlac075

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Garcia, M. R., Feng, Y., Vasudevaraja, V., Galbraith, K., Serrano, J., Thomas, C., Radmanesh, A., Hidalgo, E. T., Harter, D. H., Allen, J. C., Gardner, S. L., Osorio, D. S., William, C. M., Zagzag, D., Boué, D. R., & Snuderl, M. (2022). Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. Journal of Neuropathology and Experimental Neurology, 81(11), 865-872. https://doi.org/10.1093/jnen/nlac075

Garcia, MR, Feng, Y, Vasudevaraja, V, Galbraith, K, Serrano, J, Thomas, C, Radmanesh, A, Hidalgo, ET, Harter, DH, Allen, JC, Gardner, SL, Osorio, DS, William, CM, Zagzag, D, Boué, DR & Snuderl, M 2022, 'Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas', Journal of Neuropathology and Experimental Neurology, vol. 81, no. 11, pp. 865-872. https://doi.org/10.1093/jnen/nlac075

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abstract = "Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1-82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.",

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AU - Garcia, Mekka R.

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AU - Galbraith, Kristyn

AU - Serrano, Jonathan

AU - Thomas, Cheddhi

AU - Radmanesh, Alireza

AU - Hidalgo, Eveline T.

AU - Harter, David H.

AU - Allen, Jeffrey C.

AU - Gardner, Sharon L.

AU - Osorio, Diana S.

AU - William, Christopher M.

AU - Zagzag, David

AU - Boué, Daniel R.

AU - Snuderl, Matija

PY - 2022/11/1

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N2 - Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1-82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.

AB - Diffuse spinal cord gliomas (SCGs) are rare tumors associated with a high morbidity and mortality that affect both pediatric and adult populations. In this retrospective study, we sought to characterize the clinical, pathological, and molecular features of diffuse SCG in 22 patients with histological and molecular analyses. The median age of our cohort was 23.64 years (range 1-82) and the overall median survival was 397 days. K27M mutation was significantly more prevalent in males compared to females. Gross total resection and chemotherapy were associated with improved survival, compared to biopsy and no chemotherapy. While there was no association between tumor grade, K27M status (p = 0.366) or radiation (p = 0.772), and survival, males showed a trend toward shorter survival. K27M mutant tumors showed increased chromosomal instability and a distinct DNA methylation signature.

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KW - Neuro-oncology

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Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas

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Keywords

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