Clinical, radiological, and biochemical features of a bilateral buttock amyloidoma emerging after 27 years of hemodialysis

Giovanni Montagna, Sara Raimondi, Guido Moro, Carla Uggetti, Annalisa Relini, Umberto Magrini, Gennaro Esposito, Sofia Giorgetti, Luigi Congi, Mario Mosconi, Giovanni Galli, Giuseppe Villa, Siro Segagni, Simona Donadei, Laura Obici, Giampaolo Merlini, Monica Stoppini, Vittorio Bellotti

Research output: Contribution to journalArticle

Abstract

Deposition of amyloid in the buttock is a rare complication of dialysis related amyloidosis DRA, but this localization is even rarer in other types of amyloidoses. We report here the clinical, radiological, and biochemical features of a patient who incurred into this complication after 27 years of hemodialysis. Imaging of the amyloid deposition by magnetic resonance imaging MRI documents the amyloid infiltration in the muscles of the buttock region and highlights a peculiar feature of amyloid fibrils deposition in the subcutaneous fat. The amyloid deposition is confirmed by biochemical and microscopic analysis of fibrils extracted from a biopsy specimen. Review of literature and the features of this case lead to speculation that the peculiar involvement of the buttock region including muscles and subcutaneous fat in DRA might derive from the propagation of amyloid initially deposited in the hip joint.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalAmyloid
Volume16
Issue number3
DOIs
StatePublished - 2009

Keywords

  • Dialysis related amyloidosis
  • Subcutaneous Aβ2M amyloidoma
  • β2-microglobulin

ASJC Scopus subject areas

  • Internal Medicine

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    Montagna, G., Raimondi, S., Moro, G., Uggetti, C., Relini, A., Magrini, U., Esposito, G., Giorgetti, S., Congi, L., Mosconi, M., Galli, G., Villa, G., Segagni, S., Donadei, S., Obici, L., Merlini, G., Stoppini, M., & Bellotti, V. (2009). Clinical, radiological, and biochemical features of a bilateral buttock amyloidoma emerging after 27 years of hemodialysis. Amyloid, 16(3), 115-121. https://doi.org/10.1080/13506120903090783