Clinical relevance of systemic and local IGF-I.

Shoshana Yakar, Patricia Pennisi, Yiping Wu, Hong Zhao, Derek LeRoith

Research output: Contribution to journalReview articlepeer-review


The insulin-like growth factor family of ligands, receptors and binding proteins are critical for many normal physiological functions. These include normal development during fetal and post-natal development and maintenance of organ function in adult life. Circulating IGF-I is produced primarily by the liver under GH control, whereas the production of tissue IGF-I has other controls. Recent studies have demonstrated that both circulating and tissue IGF-I are important for maintaining the normal structure-function of complex organs such as bone. Circulating IGF-I is important for maintaining ambient GH levels; in its absence GH elevation is seen leading to insulin resistance. In addition, low levels of circulating IGF-I retard the progression and metastatic potential of a number of cancers.

Original languageEnglish (US)
Pages (from-to)11-16
Number of pages6
JournalEndocrine development
StatePublished - 2005

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems


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