Cloning of ascidian homeobox genes provides evidence for a primordial chordate cluster

Anna Di Gregorio, Antonietta Spagnuolo, Filomena Ristoratore, Michele Pischetola, Francesco Aniello, Margherita Branno, Lucio Cariello, Roberto Di Lauro

Research output: Contribution to journalArticlepeer-review

Abstract

In order to isolate genes important in controlling embryonic development in Tunicates, a genomic library from the ascidian Ciona intestinalis was screened with a degenerate oligodeoxyribonucleotide encoding the third helix of Antennapedia-type homeoboxes. Fourteen C. intestinalis homeobox genes, corresponding to several classes of homeodomains, have been identified. Five of the isolated homeoboxes show their highest homology to members of the Vertebrate HOX clusters. mRNAs for two of the isolated homeoboxes are present in unfertilized C. intestinalis eggs.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalGene
Volume156
Issue number2
DOIs
StatePublished - Apr 24 1995

Keywords

  • Distal-less
  • HLX
  • Hox
  • IPF1
  • NK
  • Tunicate
  • development
  • homeodomain
  • paired
  • sea squirt

ASJC Scopus subject areas

  • Genetics

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