Co-salen complexes as catalysts for the asymmetric Henry reaction - Reversed enantioselectivity through simple ligand modification

J. Dimroth, M. Weck

Research output: Contribution to journalArticle

Abstract

The asymmetric Henry reaction is an efficient method for the synthesis of enantioenriched nitro alcohols. We investigated the catalytic activity and enantioselectivity of derivatives of Co-salen [salen = N,N′-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamine] in this reaction. Tetrahydro-salen (salan) complexes displayed a reversed enantioselectivity compared to their Schiff-base counterparts. Oligomeric Co-salen catalysts showed a higher activity than their small molecule analogues, indicating a bimetallic pathway.

Original languageEnglish (US)
Pages (from-to)29108-29113
Number of pages6
JournalRSC Advances
Volume5
Issue number37
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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