Cognitive dysfunction in young subjects with periodontal disease

Research output: Contribution to specialist publicationArticle


Background: Periodontal disease is an inflammatory, dysbiotic condition. Studies have shown that in the elderly, periodontal disease was associated with cognitive dysfunction and Alzheimer’s disease. Objective: To investigate whether young healthy subjects with periodontal disease have lower cognition compared to those without periodontal disease. The salivary cytokines (IL-1β, TNF-α) levels in relation to cognition were also tested. Methods: In a monocenter, cross-sectional study, forty subjects [mean age (SD) = 34 (5) and 48% female] from western Romania were classified into periodontal disease conditions using radiographic assessment: 10 subjects had aggressive periodontitis (AGG_P), 20 chronic mild-moderate periodontitis (CR_P), and 10 no periodontitis (NL_P). Neuropsychological assessment performed by standardized neurologists and psychologist included Rey Auditory Verbal Learning Test (RAVLT), Montreal Cognitive Assessment test (MOCA), Mini-Mental State Examination (MMSE), and Prague tests. Salivary cytokines levels were determined by ELISA. Results: RAVLT and MOCA delayed recall scores were lower in AGG_P group compared to NL_P and CR_P. The learning curve was also different with subjects with AGG_P showing reduced learning performance. Contrary to our hypothesis, salivary IL-1β associated with immediate but not delayed cognitive scores. Conclusions: These results showed for the first time that subjects with AGG_P had cognitive dysfunction and IL-1β may play a role in this process.

Original languageEnglish (US)
Number of pages9
Specialist publicationNeurological Sciences
StatePublished - Nov 2021


  • Alzheimer's disease
  • cognitive dysfunction
  • episodic memory
  • neuropsychological assessment
  • periodontal disease
  • salivary cytokines
  • Cognitive Dysfunction/etiology
  • Cross-Sectional Studies
  • Humans
  • Periodontal Diseases/complications
  • Male
  • Mental Status and Dementia Tests
  • Alzheimer Disease
  • Neuropsychological Tests
  • Female
  • Aged

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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