Abstract
Background: Periodontal disease is an inflammatory, dysbiotic condition. Studies have shown that in the elderly, periodontal disease was associated with cognitive dysfunction and Alzheimer’s disease. Objective: To investigate whether young healthy subjects with periodontal disease have lower cognition compared to those without periodontal disease. The salivary cytokines (IL-1β, TNF-α) levels in relation to cognition were also tested. Methods: In a monocenter, cross-sectional study, forty subjects [mean age (SD) = 34 (5) and 48% female] from western Romania were classified into periodontal disease conditions using radiographic assessment: 10 subjects had aggressive periodontitis (AGG_P), 20 chronic mild-moderate periodontitis (CR_P), and 10 no periodontitis (NL_P). Neuropsychological assessment performed by standardized neurologists and psychologist included Rey Auditory Verbal Learning Test (RAVLT), Montreal Cognitive Assessment test (MOCA), Mini-Mental State Examination (MMSE), and Prague tests. Salivary cytokines levels were determined by ELISA. Results: RAVLT and MOCA delayed recall scores were lower in AGG_P group compared to NL_P and CR_P. The learning curve was also different with subjects with AGG_P showing reduced learning performance. Contrary to our hypothesis, salivary IL-1β associated with immediate but not delayed cognitive scores. Conclusions: These results showed for the first time that subjects with AGG_P had cognitive dysfunction and IL-1β may play a role in this process.
Original language | English (US) |
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Pages | 4511-4519 |
Number of pages | 9 |
Volume | 42 |
No | 11 |
Specialist publication | Neurological Sciences |
DOIs | |
State | Published - Nov 2021 |
Keywords
- Alzheimer's disease
- cognitive dysfunction
- episodic memory
- neuropsychological assessment
- periodontal disease
- salivary cytokines
- Cognitive Dysfunction/etiology
- Cross-Sectional Studies
- Humans
- Periodontal Diseases/complications
- Male
- Mental Status and Dementia Tests
- Alzheimer Disease
- Neuropsychological Tests
- Female
- Aged
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Dermatology