Colloids with valence and specific directional bonding

Yu Wang, Yufeng Wang, Dana R. Breed, Vinothan N. Manoharan, Lang Feng, Andrew D. Hollingsworth, Marcus Weck, David J. Pine

Research output: Contribution to journalArticlepeer-review


The ability to design and assemble three-dimensional structures from colloidal particles is limited by the absence of specific directional bonds. As a result, complex or low-coordination structures, common in atomic and molecular systems, are rare in the colloidal domain. Here we demonstrate a general method for creating the colloidal analogues of atoms with valence: colloidal particles with chemically distinct surface patches that imitate hybridized atomic orbitals, including sp, sp2, sp3, sp3 d, sp3 d2 and sp3 d3. Functionalized with DNA with single-stranded sticky ends, patches on different particles can form highly directional bonds through programmable, specific and reversible DNA hybridization. These features allow the particles to self-assemble into 'colloidal molecules' with triangular, tetrahedral and other bonding symmetries, and should also give access to a rich variety of new microstructured colloidal materials.

Original languageEnglish (US)
Pages (from-to)51-55
Number of pages5
Issue number7422
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • General


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