Combination HIV prevention: Significance, challenges, and opportunities

Ann E. Kurth, Connie Celum, Jared M. Baeten, Sten H. Vermund, Judith N. Wasserheit

Research output: Contribution to journalReview articlepeer-review


No single HIV prevention strategy will be sufficient to control the HIV pandemic. However, a growing number of interventions have shown promise in partially protecting against HIV transmission and acquisition, including knowledge of HIV serostatus, behavioral risk reduction, condoms, male circumcision, needle exchange, treatment of curable sexually transmitted infections, and use of systemic and topical antiretroviral medications by both HIV-infected and uninfected persons. Designing the optimal package of interventions that matches the epidemiologic profile of a target population, delivering that package at the population level, and evaluating safety, acceptability, coverage, and effectiveness, all involve methodological challenges. Nonetheless, there is an unprecedented opportunity to develop "prevention packages" that combine various arrays of evidence-based strategies, tailored to the needs of diverse subgroups and targeted to achieve high coverage for a measurable reduction in population-level HIV transmission. HIV prevention strategies that combine partially effective interventions should be scaled up and evaluated.

Original languageEnglish (US)
Pages (from-to)62-72
Number of pages11
JournalCurrent HIV/AIDS Reports
Issue number1
StatePublished - Mar 2011


  • Antiretroviral therapy
  • Combination HIV prevention
  • HIV prevention methods
  • HIV prevention packages
  • Test and treat

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


Dive into the research topics of 'Combination HIV prevention: Significance, challenges, and opportunities'. Together they form a unique fingerprint.

Cite this