Combined optical tomographic and magnetic resonance imaging of tumor bearing mice

J. Masciotti, G. Abdoulaev, J. Hur, J. Papa, J. Bae, J. Huang, D. Yamashiro, J. Kandel, A. H. Hielscher

    Research output: Contribution to journalConference articlepeer-review

    Abstract

    With the advent of small animal imaging systems, it has become possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images as well as studying cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2). Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution and insensitive to CBF, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and CBV with high temporal resolution. In this study we present our first results concerning coregistration of MRI and optical data. By applying both modalities to imaging of kidney tumors in mice that undergo VEGF treatment, we illustrate how these imaging modalities can supplement each other and cross validation can be performed.

    Original languageEnglish (US)
    Article number13
    Pages (from-to)74-81
    Number of pages8
    JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
    Volume5693
    DOIs
    StatePublished - 2005
    EventOptical Tomography and Spectroscopy of Tissue VI - San Jose, CA, United States
    Duration: Jan 23 2005Jan 26 2005

    Keywords

    • MRI
    • Multimodality imaging
    • Optical tomography
    • Small animal imaging

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Radiology Nuclear Medicine and imaging

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