TY - GEN
T1 - Combined optical tomographic and magnetic resonance imaging of tumor bearing mice
AU - Masciotti, J.
AU - Abdoulaev, G.
AU - Hur, J.
AU - Papa, J.
AU - Bae, J.
AU - Huang, J.
AU - Yamashiro, D.
AU - Kandel, J.
AU - Hielscher, A. H.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2005
Y1 - 2005
N2 - With the advent of small animal imaging systems, it has become possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images as well as studying cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2). Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution and insensitive to CBF, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and CBV with high temporal resolution. In this study we present our first results concerning coregistration of MRI and optical data. By applying both modalities to imaging of kidney tumors in mice that undergo VEGF treatment, we illustrate how these imaging modalities can supplement each other and cross validation can be performed.
AB - With the advent of small animal imaging systems, it has become possible to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images as well as studying cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2). Optical tomography, on the other hand, is an emerging imaging modality, which, while much lower in spatial resolution and insensitive to CBF, can separate the effects of oxyhemoglobin, deoxyhemoglobin, and CBV with high temporal resolution. In this study we present our first results concerning coregistration of MRI and optical data. By applying both modalities to imaging of kidney tumors in mice that undergo VEGF treatment, we illustrate how these imaging modalities can supplement each other and cross validation can be performed.
KW - MRI
KW - Multimodality imaging
KW - Optical tomography
KW - Small animal imaging
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U2 - 10.1117/12.590844
DO - 10.1117/12.590844
M3 - Conference contribution
AN - SCOPUS:23244460723
VL - 5693
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
SP - 74
EP - 81
BT - Optical Tomography and Spectroscopy of Tissue VI
T2 - Optical Tomography and Spectroscopy of Tissue VI
Y2 - 23 January 2005 through 26 January 2005
ER -