Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates

Rishi K. Jain; Lun K. Tsou; Andrew D. Hamilton

doi:10.1016/j.tetlet.2009.03.153

Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates

Rishi K. Jain, Lun K. Tsou, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.

Original language	English (US)
Pages (from-to)	2787-2789
Number of pages	3
Journal	Tetrahedron Letters
Volume	50
Issue number	23
DOIs	https://doi.org/10.1016/j.tetlet.2009.03.153
State	Published - Jun 10 2009

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2009.03.153

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title = "Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates",

abstract = "A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.",

author = "Jain, {Rishi K.} and Tsou, {Lun K.} and Hamilton, {Andrew D.}",

note = "Funding Information: We thank the National Institutes of Health (GM 35208) for financial support of this work.",

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AU - Jain, Rishi K.

AU - Tsou, Lun K.

AU - Hamilton, Andrew D.

N1 - Funding Information: We thank the National Institutes of Health (GM 35208) for financial support of this work.

PY - 2009/6/10

Y1 - 2009/6/10

N2 - A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.

AB - A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.

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M3 - Article

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

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Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates

Abstract

ASJC Scopus subject areas

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