Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates

Rishi K. Jain, Lun K. Tsou, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.

Original languageEnglish (US)
Pages (from-to)2787-2789
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number23
DOIs
StatePublished - Jun 10 2009

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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