TY - JOUR
T1 - Comparative evolutionary genomics of human malaria parasites
AU - Carlton, Jane M.
AU - Escalante, Ananias A.
AU - Neafsey, Daniel
AU - Volkman, Sarah K.
N1 - Funding Information:
This work was supported by National Institute of General Medical Sciences, National Institutes of Health grant RO1 GM070793 to J.M.C. and R01 GM080586 to A.A.E.
PY - 2008/12
Y1 - 2008/12
N2 - The parasites Plasmodium falciparum and Plasmodium vivax are responsible for the majority of human malaria cases worldwide. Despite many similarities in their biology, they frequently are studied in isolation. With the completion of the P. vivax genome and the generation of an initial P. falciparum genetic diversity map, attempts are being made to infer inter- and intra-species genome evolution. Here, we briefly review our current knowledge of comparative evolutionary genomics of the two species in the light of several presentations at the Molecular Approaches to Malaria 2008 meeting in Lorne, Australia and ask the question: can evolutionary genomics of one species inform the other?
AB - The parasites Plasmodium falciparum and Plasmodium vivax are responsible for the majority of human malaria cases worldwide. Despite many similarities in their biology, they frequently are studied in isolation. With the completion of the P. vivax genome and the generation of an initial P. falciparum genetic diversity map, attempts are being made to infer inter- and intra-species genome evolution. Here, we briefly review our current knowledge of comparative evolutionary genomics of the two species in the light of several presentations at the Molecular Approaches to Malaria 2008 meeting in Lorne, Australia and ask the question: can evolutionary genomics of one species inform the other?
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U2 - 10.1016/j.pt.2008.09.003
DO - 10.1016/j.pt.2008.09.003
M3 - Review article
C2 - 18938107
AN - SCOPUS:55549119917
SN - 1471-4922
VL - 24
SP - 545
EP - 550
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 12
ER -