Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice

Wieslawa Kosinska; Edward Pelle; Marcia d.M. Von Pressentin; Michael Chen; Joseph B. Guttenplan

doi:10.1016/S0304-3835(02)00382-8

Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice

Wieslawa Kosinska, Edward Pelle, Marcia d.M. Von Pressentin, Michael Chen, Joseph B. Guttenplan

Molecular Pathobiology

Research output: Contribution to journal › Article › peer-review

Abstract

Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.

Original language	English (US)
Pages (from-to)	41-46
Number of pages	6
Journal	Cancer Letters
Volume	187
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(02)00382-8
State	Published - Dec 10 2002

Keywords

Bleomycin
Ferric nitrilotriacetate
Mutagenesis
Reactive oxygen species
lacZ

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(02)00382-8

Cite this

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title = "Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice",

abstract = "Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.",

keywords = "Bleomycin, Ferric nitrilotriacetate, Mutagenesis, Reactive oxygen species, lacZ",

author = "Wieslawa Kosinska and Edward Pelle and {Von Pressentin}, {Marcia d.M.} and Michael Chen and Guttenplan, {Joseph B.}",

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AU - Kosinska, Wieslawa

AU - Pelle, Edward

AU - Von Pressentin, Marcia d.M.

AU - Chen, Michael

AU - Guttenplan, Joseph B.

N1 - Funding Information: Supported by NIH grant no. CA76281.

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AB - Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.

KW - Bleomycin

KW - Ferric nitrilotriacetate

KW - Mutagenesis

KW - Reactive oxygen species

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Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice

Abstract

Keywords

ASJC Scopus subject areas

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