Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice

Wieslawa Kosinska, Edward Pelle, Marcia d.M. Von Pressentin, Michael Chen, Joseph B. Guttenplan

Research output: Contribution to journalArticlepeer-review

Abstract

Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.

Original languageEnglish (US)
Pages (from-to)41-46
Number of pages6
JournalCancer Letters
Volume187
Issue number1-2
DOIs
StatePublished - Dec 10 2002

Keywords

  • Bleomycin
  • Ferric nitrilotriacetate
  • Mutagenesis
  • Reactive oxygen species
  • lacZ

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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