Comparing the tolerability and effectiveness of two treatment regimens in a smoking clinic

Scott E. Sherman, Ileana Aldana, Maribel Estrada, Laura York

Research output: Contribution to journalArticlepeer-review


This study compares the effectiveness and tolerability of bupropion versus bupropion plus nicotine patch for smoking cessation in a routine clinical setting. Patients at the Sepulveda Veterans Health Administration Smoking Cessation Clinic completed a baseline survey and received counseling over 2 months, along with bupropion or bupropion plus nicotine patch. Of the 227 patients randomized to treatment, 112 (49%) received bupropion only and 115 (51%) received the combination therapy. At least one side effect was noted in 55% of bupropion patients and 70% of combination therapy patients; treatment regimens were changed in 7% and 14%, respectively. Abstinence rates at 2 months were 26% for the bupropion group and 37% for the combination therapy group (p = 0.1), and at 6 months were 42% versus 35%, respectively (p = 0.4). Although 6-month abstinence rates were derived from patient self-report and should be interpreted with caution, these results suggest that most patients referred to the clinic are able to take these medications. There was no difference in the rate of switching treatments, or in long-term abstinence rates.

Original languageEnglish (US)
Pages (from-to)550-554
Number of pages5
JournalMilitary Medicine
Issue number6
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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