Comparing whole genomes using DNA microarrays

David Gresham, Maitreya J. Dunham, David Botstein

Research output: Contribution to journalReview article

Abstract

The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis of inter- and intra-individual genome variation within a species on a routine basis. Sequencing whole genomes requires resources that are currently beyond those of a single laboratory and therefore it is not a practical approach for resequencing hundreds of individual genomes. DNA microarrays present an alternative way to study differences between closely related genomes. Advances in microarray-based approaches have enabled the main forms of genomic variation (amplifications, deletions, insertions, rearrangements and base-pair changes) to be detected using techniques that are readily performed in individual laboratories using simple experimental approaches.

Original languageEnglish (US)
Pages (from-to)291-302
Number of pages12
JournalNature Reviews Genetics
Volume9
Issue number4
DOIs
StatePublished - Apr 2008

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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