Comparison of contrast enhancement and diffusion-weighted magnetic resonance imaging in healthy and cancerous breast tissue

Gene Young Cho, Linda Moy, Sungheon G. Kim, Ana Paula Klautau Leite, Steven H. Baete, James S. Babb, Daniel K. Sodickson, Eric E. Sigmund

    Research output: Contribution to journalArticle

    Abstract

    Objective To measure background parenchymal enhancement (BPE) and compare with other contrast enhancement values and diffusion-weighted MRI parameters in healthy and cancerous breast tissue at the clinical level. Materials and methods This HIPAA-compliant, IRB approved retrospective study enrolled 77 patients (38 patients with breast cancer - mean age 51.8 ± 10.0 years; 39 high-risk patients for screening evaluation - mean age 46.3 ± 11.7 years), who underwent contrast-enhanced 3T breast MRI. Contrast enhanced MRI and diffusion-weighted imaging were performed to quantify BPE, lesion contrast enhancement, and apparent diffusion coefficient (ADC) metrics in fibroglandular tissue (FGT) and lesions. Results BPE did not correlate with ADC values. Mean BPE for the lesion-bearing patients was higher (43.9%) compared to that of the high-risk screening patients (28.3%, p = 0.004). Significant correlation (r = 0.37, p < 0.05) was found between BPE and lesion contrast enhancement. Conclusion No significant association was observed between parenchymal or lesion enhancement with conventional apparent diffusion metrics, suggesting that proliferative processes are not co-regulated in cancerous and parenchymal tissue.

    Original languageEnglish (US)
    Pages (from-to)1888-1893
    Number of pages6
    JournalEuropean Journal of Radiology
    Volume84
    Issue number10
    DOIs
    StatePublished - Oct 1 2015

    Keywords

    • 3 Tesla
    • Background parenchymal enhancement
    • Breast MR
    • Diffusion-weighted imaging
    • Dynamic contrast enhancement

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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  • Cite this

    Cho, G. Y., Moy, L., Kim, S. G., Klautau Leite, A. P., Baete, S. H., Babb, J. S., Sodickson, D. K., & Sigmund, E. E. (2015). Comparison of contrast enhancement and diffusion-weighted magnetic resonance imaging in healthy and cancerous breast tissue. European Journal of Radiology, 84(10), 1888-1893. https://doi.org/10.1016/j.ejrad.2015.06.023