TY - JOUR
T1 - Comparison of contrast enhancement and diffusion-weighted magnetic resonance imaging in healthy and cancerous breast tissue
AU - Cho, Gene Young
AU - Moy, Linda
AU - Kim, Sungheon G.
AU - Klautau Leite, Ana Paula
AU - Baete, Steven H.
AU - Babb, James S.
AU - Sodickson, Daniel K.
AU - Sigmund, Eric E.
N1 - Publisher Copyright:
© 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Objective To measure background parenchymal enhancement (BPE) and compare with other contrast enhancement values and diffusion-weighted MRI parameters in healthy and cancerous breast tissue at the clinical level. Materials and methods This HIPAA-compliant, IRB approved retrospective study enrolled 77 patients (38 patients with breast cancer - mean age 51.8 ± 10.0 years; 39 high-risk patients for screening evaluation - mean age 46.3 ± 11.7 years), who underwent contrast-enhanced 3T breast MRI. Contrast enhanced MRI and diffusion-weighted imaging were performed to quantify BPE, lesion contrast enhancement, and apparent diffusion coefficient (ADC) metrics in fibroglandular tissue (FGT) and lesions. Results BPE did not correlate with ADC values. Mean BPE for the lesion-bearing patients was higher (43.9%) compared to that of the high-risk screening patients (28.3%, p = 0.004). Significant correlation (r = 0.37, p < 0.05) was found between BPE and lesion contrast enhancement. Conclusion No significant association was observed between parenchymal or lesion enhancement with conventional apparent diffusion metrics, suggesting that proliferative processes are not co-regulated in cancerous and parenchymal tissue.
AB - Objective To measure background parenchymal enhancement (BPE) and compare with other contrast enhancement values and diffusion-weighted MRI parameters in healthy and cancerous breast tissue at the clinical level. Materials and methods This HIPAA-compliant, IRB approved retrospective study enrolled 77 patients (38 patients with breast cancer - mean age 51.8 ± 10.0 years; 39 high-risk patients for screening evaluation - mean age 46.3 ± 11.7 years), who underwent contrast-enhanced 3T breast MRI. Contrast enhanced MRI and diffusion-weighted imaging were performed to quantify BPE, lesion contrast enhancement, and apparent diffusion coefficient (ADC) metrics in fibroglandular tissue (FGT) and lesions. Results BPE did not correlate with ADC values. Mean BPE for the lesion-bearing patients was higher (43.9%) compared to that of the high-risk screening patients (28.3%, p = 0.004). Significant correlation (r = 0.37, p < 0.05) was found between BPE and lesion contrast enhancement. Conclusion No significant association was observed between parenchymal or lesion enhancement with conventional apparent diffusion metrics, suggesting that proliferative processes are not co-regulated in cancerous and parenchymal tissue.
KW - 3 Tesla
KW - Background parenchymal enhancement
KW - Breast MR
KW - Diffusion-weighted imaging
KW - Dynamic contrast enhancement
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U2 - 10.1016/j.ejrad.2015.06.023
DO - 10.1016/j.ejrad.2015.06.023
M3 - Article
C2 - 26220915
AN - SCOPUS:84941802201
SN - 0720-048X
VL - 84
SP - 1888
EP - 1893
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 10
ER -