TY - JOUR
T1 - Comparison of past versus recent physical activity in the prevention of premature death and coronary artery disease
AU - Sherman, S. E.
AU - D'Agostino, R. B.
AU - Silbershatz, H.
AU - Kannel, W. B.
N1 - Funding Information:
Supported by the Framingham Heart Study Visiting Scholar’s Fund, which includes support from the National Heart, Lung, and Blood Institute; ICI Pharma; Merck, Sharp, and Dohme; and Pfizer Inc; and by UCLA Claude G. Pepper Older Americans Independence Center, National Institute on Aging (#AG 10415-01).
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1999
Y1 - 1999
N2 - Background: People who are physically active live longer, but it is unclear whether this is because of physical activity in the distant or more recent past. Methods: We assessed activity levels in 5209 men and women in the Framingham Heart Study from 1956 to 1958 and again from 1969 to 1973. We included individuals who were alive and without cardiovascular disease in the period 1969 to 1973. The primary outcome was death from all causes during the 16 years after the 1969 to 1973 assessment. Secondary outcomes were incidence and mortality rate of cardiovascular disease. We used Cox proportional hazards regression to calculate the relative risk of being sedentary, both unadjusted and controlling for smoking, weight, systolic blood pressure, cholesterol, glucose intolerance, left ventricular hypertrophy, chronic obstructive pulmonary disease, and cancer. Results: The overall 16-year mortality rate was 37% for men and 27% for women. When both distant and recent activity levels were included along with major cardiovascular disease risk factors, for recent activity the most active fertile had lower overall mortality rate than the least active fertile for men (risk ratio 0.58, 95% confidence interval, 0.43-0.79) and women (risk ratio 0.61,95% confidence interval 0.45-0.82). For distant activity there was no difference in overall mortality rate between the most and least active tertiles either for men or for women. Adjusting for major cardiovascular disease risk factors had little effect on the results. Conclusions: The reduction in overall mortality rates is more associated with recent activity than distant activity. These results suggest that for sedentary patients, it may never be too late to begin exercising.
AB - Background: People who are physically active live longer, but it is unclear whether this is because of physical activity in the distant or more recent past. Methods: We assessed activity levels in 5209 men and women in the Framingham Heart Study from 1956 to 1958 and again from 1969 to 1973. We included individuals who were alive and without cardiovascular disease in the period 1969 to 1973. The primary outcome was death from all causes during the 16 years after the 1969 to 1973 assessment. Secondary outcomes were incidence and mortality rate of cardiovascular disease. We used Cox proportional hazards regression to calculate the relative risk of being sedentary, both unadjusted and controlling for smoking, weight, systolic blood pressure, cholesterol, glucose intolerance, left ventricular hypertrophy, chronic obstructive pulmonary disease, and cancer. Results: The overall 16-year mortality rate was 37% for men and 27% for women. When both distant and recent activity levels were included along with major cardiovascular disease risk factors, for recent activity the most active fertile had lower overall mortality rate than the least active fertile for men (risk ratio 0.58, 95% confidence interval, 0.43-0.79) and women (risk ratio 0.61,95% confidence interval 0.45-0.82). For distant activity there was no difference in overall mortality rate between the most and least active tertiles either for men or for women. Adjusting for major cardiovascular disease risk factors had little effect on the results. Conclusions: The reduction in overall mortality rates is more associated with recent activity than distant activity. These results suggest that for sedentary patients, it may never be too late to begin exercising.
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U2 - 10.1016/S0002-8703(99)70015-3
DO - 10.1016/S0002-8703(99)70015-3
M3 - Article
C2 - 10539821
AN - SCOPUS:0032717837
SN - 0002-8703
VL - 138
SP - 900
EP - 907
JO - American Heart Journal
JF - American Heart Journal
IS - 5 I
ER -