TY - JOUR
T1 - Comparison of relative mandibular growth vectors with high-resolution 3-dimensional imaging
AU - Cevidanes, Lucia H.S.
AU - Franco, Alexandre A.
AU - Gerig, Guido
AU - Proffit, William R.
AU - Slice, Dennis E.
AU - Enlow, Donald H.
AU - Lederman, Henrique M.
AU - Amorim, Leila
AU - Scanavini, Marco A.
AU - Vigorito, Julio W.
N1 - Funding Information:
CNPq, a Brazilian governmental agency for scientific and technological development, scholarship 20005-98/7, supported work by L.H.S.C. FAPESP-Brazil grant 97/01388-8 supported work by A.A.F., J.W.V., H.K.Y., and M.A.S. UNC Dental Research Center supported work by L.A. and G.G. Work by D.E.S. was supported, in part, by the Austrian Ministry of Education, Science, and Culture, the Austrian Council for Science and Technology (grant number: AD 387/25-30 to Horst Seidler), Dr Edward G. Hill, and members of the Winston-Salem community.
PY - 2005/7
Y1 - 2005/7
N2 - Introduction: The mandibular rami and their endochondrally growing condyles develop in many directions relative to the variable anatomic patterns of the nasomaxilla and middle cranial fossae during growth and response to orthopedic treatment. Methods: High-resolution magnetic resonance images were used to compare 3-dimensional (3D) growth vectors of skeletal displacement and bone remodeling in 25 untreated subjects with Class II malocclusions, 28 subjects with Class II malocclusions who were treated with Fränkel appliance therapy, and 25 subjects with normal occlusions. Marked differences were noted over an 18-month observation period. The 3D coordinates of anatomic landmarks were registered by Procrustes fit to control for rotation, translation, and scale differences. Results: Compared with untreated Class II and normal-occlusion subjects, the treated group showed highly significant differences in the 3D displacement/remodeling vectors of gonion and pterygomaxillary fissure relative to condylion and middle cranial fossae bilateral skeletal landmarks, by using both permutation tests (P < .001) and a general linear multivariate model (P < .0001). Conclusions: In a prospective and systematically controlled study, we quantitatively described significant 3D rami skeletal compensations in the structural assembly of facial morphogenesis at the beginning of the adolescent growth spurt using novel modeling techniques. These techniques have facilitated quantification of relative 3D growth vectors to illustrate skeletal changes with Fränkel appliance therapy. Future studies are required to assess the long-term clinical significance of our findings.
AB - Introduction: The mandibular rami and their endochondrally growing condyles develop in many directions relative to the variable anatomic patterns of the nasomaxilla and middle cranial fossae during growth and response to orthopedic treatment. Methods: High-resolution magnetic resonance images were used to compare 3-dimensional (3D) growth vectors of skeletal displacement and bone remodeling in 25 untreated subjects with Class II malocclusions, 28 subjects with Class II malocclusions who were treated with Fränkel appliance therapy, and 25 subjects with normal occlusions. Marked differences were noted over an 18-month observation period. The 3D coordinates of anatomic landmarks were registered by Procrustes fit to control for rotation, translation, and scale differences. Results: Compared with untreated Class II and normal-occlusion subjects, the treated group showed highly significant differences in the 3D displacement/remodeling vectors of gonion and pterygomaxillary fissure relative to condylion and middle cranial fossae bilateral skeletal landmarks, by using both permutation tests (P < .001) and a general linear multivariate model (P < .0001). Conclusions: In a prospective and systematically controlled study, we quantitatively described significant 3D rami skeletal compensations in the structural assembly of facial morphogenesis at the beginning of the adolescent growth spurt using novel modeling techniques. These techniques have facilitated quantification of relative 3D growth vectors to illustrate skeletal changes with Fränkel appliance therapy. Future studies are required to assess the long-term clinical significance of our findings.
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U2 - 10.1016/j.ajodo.2004.03.033
DO - 10.1016/j.ajodo.2004.03.033
M3 - Article
C2 - 16027622
AN - SCOPUS:22244442711
SN - 0889-5406
VL - 128
SP - 27
EP - 34
JO - American Journal of Orthodontics and Dentofacial Orthopedics
JF - American Journal of Orthodontics and Dentofacial Orthopedics
IS - 1
ER -