Compensatory hyperplasia with increasing loss of renal mass

H. Van Urk; D. Malamud; L. Soler Montesinos; R. A. Malt

Compensatory hyperplasia with increasing loss of renal mass

H. Van Urk, D. Malamud, L. Soler Montesinos, R. A. Malt

Research output: Contribution to journal › Article › peer-review

Abstract

When a rat with two kidneys is cross-circulated with an anephric rat, compensatory renal hypertrophy occurs as indicated by an increased ratio of RNA to DNA within 6 hours and an increased ratio of kidney weight to body weight within 12 hours. Removal of three kidneys between the rats further increases residual renal mass and RNA/DNA after 24 and 48 hours of cross-circulation as compared with results of removing two kidneys. Trinephrectomy triples the mitotic index and doubles the proliferative index. Increasing the magnitude of renal loss causes appreciable hyperplasia as well as increasing the magnitude of compensatory renal hypertrophy.

Original language	English (US)
Pages (from-to)	674-676
Number of pages	3
Journal	Laboratory Investigation
Volume	38
Issue number	6
State	Published - 1978

ASJC Scopus subject areas

General Medicine

Cite this

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title = "Compensatory hyperplasia with increasing loss of renal mass",

abstract = "When a rat with two kidneys is cross-circulated with an anephric rat, compensatory renal hypertrophy occurs as indicated by an increased ratio of RNA to DNA within 6 hours and an increased ratio of kidney weight to body weight within 12 hours. Removal of three kidneys between the rats further increases residual renal mass and RNA/DNA after 24 and 48 hours of cross-circulation as compared with results of removing two kidneys. Trinephrectomy triples the mitotic index and doubles the proliferative index. Increasing the magnitude of renal loss causes appreciable hyperplasia as well as increasing the magnitude of compensatory renal hypertrophy.",

author = "{Van Urk}, H. and D. Malamud and {Soler Montesinos}, L. and Malt, {R. A.}",

year = "1978",

language = "English (US)",

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journal = "Laboratory Investigation",

issn = "0023-6837",

publisher = "Elsevier B.V.",

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T1 - Compensatory hyperplasia with increasing loss of renal mass

AU - Van Urk, H.

AU - Malamud, D.

AU - Soler Montesinos, L.

AU - Malt, R. A.

PY - 1978

Y1 - 1978

N2 - When a rat with two kidneys is cross-circulated with an anephric rat, compensatory renal hypertrophy occurs as indicated by an increased ratio of RNA to DNA within 6 hours and an increased ratio of kidney weight to body weight within 12 hours. Removal of three kidneys between the rats further increases residual renal mass and RNA/DNA after 24 and 48 hours of cross-circulation as compared with results of removing two kidneys. Trinephrectomy triples the mitotic index and doubles the proliferative index. Increasing the magnitude of renal loss causes appreciable hyperplasia as well as increasing the magnitude of compensatory renal hypertrophy.

AB - When a rat with two kidneys is cross-circulated with an anephric rat, compensatory renal hypertrophy occurs as indicated by an increased ratio of RNA to DNA within 6 hours and an increased ratio of kidney weight to body weight within 12 hours. Removal of three kidneys between the rats further increases residual renal mass and RNA/DNA after 24 and 48 hours of cross-circulation as compared with results of removing two kidneys. Trinephrectomy triples the mitotic index and doubles the proliferative index. Increasing the magnitude of renal loss causes appreciable hyperplasia as well as increasing the magnitude of compensatory renal hypertrophy.

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C2 - 661223

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SN - 0023-6837

VL - 38

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EP - 676

JO - Laboratory Investigation

JF - Laboratory Investigation

IS - 6

ER -

Compensatory hyperplasia with increasing loss of renal mass

Abstract

ASJC Scopus subject areas

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