Competent antigen-binding fragments (Fab) from secretory immunoglobulin a using streptococcus sanguis immunoglobulin a protease

C. P. Mallett, R. J. Boylan, D. L. Everhart

Research output: Contribution to journalArticlepeer-review

Abstract

Immunoglobulin A (IgA) protease, a family of bacterial enzymes, cleaves human IgA I at a single bond generating distinct Fab and Fc fragments. Purified secretory IgA with known specificity for Streptococcus mutans NCTC 10449 (serotype c) was hydrolyzed with IgA protease prepared from Streptococcus sanguis ATCC 10556. The isolated Fab fragments retained their initial activity by specifically binding to antigen and by deterring the sucrose-dependent adherence of S. mutans to glass indicating that the antigen-binding fragments behave as immunologically competent elements.

Original languageEnglish (US)
Pages (from-to)201-208
Number of pages8
JournalCaries research
Volume18
Issue number3
DOIs
StatePublished - 1984

Keywords

  • Antigen
  • Immunoglobulin protease
  • Streptococci

ASJC Scopus subject areas

  • Dentistry(all)

Fingerprint Dive into the research topics of 'Competent antigen-binding fragments (Fab) from secretory immunoglobulin a using streptococcus sanguis immunoglobulin a protease'. Together they form a unique fingerprint.

Cite this