Complex Genomic Rearrangements following Selection in a Glutamine-Limited Medium over Hundreds of Generations

Pieter Spealman; Grace Avecilla; Julia Matthews; Ina Suresh; David Gresham

doi:10.1128/mra.00729-22

Complex Genomic Rearrangements following Selection in a Glutamine-Limited Medium over Hundreds of Generations

Pieter Spealman, Grace Avecilla, Julia Matthews, Ina Suresh, David Gresham

Biology and Genomics

Research output: Contribution to journal › Article › peer-review

Abstract

Large-scale genomic changes, including copy number variations (CNVs), are frequently observed in long-term evolution experiments (LTEEs). We have previously reported the detection of recurrent CNVs in Saccharomyces cerevisiae populations adapting to glutamine-limited conditions over hundreds of generations. Here, we present the whole-genome sequencing (WGS) assemblies of 7 LTEE strains and their ancestor.

Original language	English (US)
Journal	Microbiology Resource Announcements
Volume	11
Issue number	11
DOIs	https://doi.org/10.1128/mra.00729-22
State	Published - Nov 2022

ASJC Scopus subject areas

Molecular Biology
Immunology and Microbiology (miscellaneous)
Genetics

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10.1128/mra.00729-22

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title = "Complex Genomic Rearrangements following Selection in a Glutamine-Limited Medium over Hundreds of Generations",

abstract = "Large-scale genomic changes, including copy number variations (CNVs), are frequently observed in long-term evolution experiments (LTEEs). We have previously reported the detection of recurrent CNVs in Saccharomyces cerevisiae populations adapting to glutamine-limited conditions over hundreds of generations. Here, we present the whole-genome sequencing (WGS) assemblies of 7 LTEE strains and their ancestor.",

author = "Pieter Spealman and Grace Avecilla and Julia Matthews and Ina Suresh and David Gresham",

note = "Funding Information: This work was made possible by grants from the NIH and NSF to P.S. (F32-GM131573), G.A. (DGE1342536), and D.G. (R01-GM134066, R01-GM107466, MCB1818234). Publisher Copyright: Copyright {\textcopyright} 2022 Spealman et al.",

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AU - Avecilla, Grace

AU - Matthews, Julia

AU - Suresh, Ina

AU - Gresham, David

N1 - Funding Information: This work was made possible by grants from the NIH and NSF to P.S. (F32-GM131573), G.A. (DGE1342536), and D.G. (R01-GM134066, R01-GM107466, MCB1818234). Publisher Copyright: Copyright © 2022 Spealman et al.

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N2 - Large-scale genomic changes, including copy number variations (CNVs), are frequently observed in long-term evolution experiments (LTEEs). We have previously reported the detection of recurrent CNVs in Saccharomyces cerevisiae populations adapting to glutamine-limited conditions over hundreds of generations. Here, we present the whole-genome sequencing (WGS) assemblies of 7 LTEE strains and their ancestor.

AB - Large-scale genomic changes, including copy number variations (CNVs), are frequently observed in long-term evolution experiments (LTEEs). We have previously reported the detection of recurrent CNVs in Saccharomyces cerevisiae populations adapting to glutamine-limited conditions over hundreds of generations. Here, we present the whole-genome sequencing (WGS) assemblies of 7 LTEE strains and their ancestor.

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Complex Genomic Rearrangements following Selection in a Glutamine-Limited Medium over Hundreds of Generations

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