Complications After Systematic, Random, and Image-guided Prostate Biopsy [figure presented]

Marco Borghesi, Hashim Ahmed, Robert Nam, Edward Schaeffer, Riccardo Schiavina, Samir Taneja, Wolfgang Weidner, Stacy Loeb

    Research output: Contribution to journalReview article

    Abstract

    Context Prostate biopsy (PB) represents the gold standard method to confirm the presence of cancer. In addition to traditional random or systematic approaches, a magnetic resonance imaging (MRI)–guided technique has been introduced recently. Objective To perform a systematic review of complications after transrectal ultrasound (TRUS)–guided, transperineal, and MRI-guided PB. Evidence acquisition We performed a systematic literature search of Web of Science, Embase, and Scopus databases up to October 2015, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Complications and mortality following random, systematic, and image-guided PBs were reviewed. Eighty-five references were included. Evidence synthesis The most frequent complication after PB was minor and self-limiting bleeding (hematuria and hematospermia), regardless of the biopsy approach. Occurrence of rectal bleeding was comparable for traditional TRUS-guided and image-guided PBs. Almost 25% of patients experienced lower urinary tract symptoms, but only a few had urinary retention, with higher rates after a transperineal approach. Temporary erectile dysfunction was not negligible, with a return to baseline after 1–6 mo. The incidence of infective complications is increasing, with higher rates among men with medical comorbidities and older age. Transperineal and in-bore MRI–targeted biopsy may reduce the risk of severe infectious complications. Mortality after PB is uncommon, regardless of biopsy technique. Conclusions Complications after PB are frequent but often self-limiting. The incidence of hospitalization due to severe infections is continuously increasing. The patient's general health status, risk factors, and likelihood of antimicrobial resistance should be carefully appraised before scheduling a PB. Patient summary We reviewed the variety and incidence of complications after prostate biopsy. Even if frequent, complications seldom represent a problem for the patient. The most troublesome complications are infections. To minimize this risk, the patient's medical condition should be carefully evaluated before biopsy.

    Original languageEnglish (US)
    Pages (from-to)353-365
    Number of pages13
    JournalEuropean Urology
    Volume71
    Issue number3
    DOIs
    StatePublished - Mar 1 2017

    Keywords

    • Complications
    • Hospitalization
    • Infection
    • MRI-guided biopsy
    • Mortality
    • Prostate biopsy

    ASJC Scopus subject areas

    • Urology

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  • Cite this

    Borghesi, M., Ahmed, H., Nam, R., Schaeffer, E., Schiavina, R., Taneja, S., Weidner, W., & Loeb, S. (2017). Complications After Systematic, Random, and Image-guided Prostate Biopsy [figure presented]. European Urology, 71(3), 353-365. https://doi.org/10.1016/j.eururo.2016.08.004