Compound stimulus extinction reduces spontaneous recovery in humans

Cesar A.O. Coelho; Joseph E. Dunsmoor; Elizabeth A. Phelps

doi:10.1101/lm.039479.115

Compound stimulus extinction reduces spontaneous recovery in humans

Cesar A.O. Coelho, Joseph E. Dunsmoor, Elizabeth A. Phelps

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Fear-related behaviors are prone to relapse following extinction. We tested in humans a compound extinction design ("deepened extinction") shown in animal studies to reduce post-extinction fear recovery. Adult subjects underwent fear conditioning to a visual and an auditory conditioned stimulus (CSA and CSB, respectively) separately paired with an electric shock. The target CS (CSA) was extinguished alone followed by compound presentations of the extinguished CSA and non-extinguished CSB. Recovery of conditioned skin conductance responses to CSA was reduced 24 h after compound extinction, as compared with a group who received an equal number of extinction trials to the CSA alone.

Original language	English (US)
Pages (from-to)	589-593
Number of pages	5
Journal	Learning and Memory
Volume	22
Issue number	12
DOIs	https://doi.org/10.1101/lm.039479.115
State	Published - Dec 2015

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Cellular and Molecular Neuroscience

Access to Document

10.1101/lm.039479.115

Cite this

@article{bef55657800241518fa4d3db5e326eff,

title = "Compound stimulus extinction reduces spontaneous recovery in humans",

abstract = "Fear-related behaviors are prone to relapse following extinction. We tested in humans a compound extinction design ({"}deepened extinction{"}) shown in animal studies to reduce post-extinction fear recovery. Adult subjects underwent fear conditioning to a visual and an auditory conditioned stimulus (CSA and CSB, respectively) separately paired with an electric shock. The target CS (CSA) was extinguished alone followed by compound presentations of the extinguished CSA and non-extinguished CSB. Recovery of conditioned skin conductance responses to CSA was reduced 24 h after compound extinction, as compared with a group who received an equal number of extinction trials to the CSA alone.",

author = "Coelho, {Cesar A.O.} and Dunsmoor, {Joseph E.} and Phelps, {Elizabeth A.}",

note = "Publisher Copyright: {\textcopyright} 2015 Coelho et al.",

year = "2015",

month = dec,

doi = "10.1101/lm.039479.115",

language = "English (US)",

volume = "22",

pages = "589--593",

journal = "Learning and Memory",

issn = "1072-0502",

publisher = "Cold Spring Harbor Laboratory Press",

number = "12",

}

TY - JOUR

T1 - Compound stimulus extinction reduces spontaneous recovery in humans

AU - Coelho, Cesar A.O.

AU - Dunsmoor, Joseph E.

AU - Phelps, Elizabeth A.

PY - 2015/12

Y1 - 2015/12

N2 - Fear-related behaviors are prone to relapse following extinction. We tested in humans a compound extinction design ("deepened extinction") shown in animal studies to reduce post-extinction fear recovery. Adult subjects underwent fear conditioning to a visual and an auditory conditioned stimulus (CSA and CSB, respectively) separately paired with an electric shock. The target CS (CSA) was extinguished alone followed by compound presentations of the extinguished CSA and non-extinguished CSB. Recovery of conditioned skin conductance responses to CSA was reduced 24 h after compound extinction, as compared with a group who received an equal number of extinction trials to the CSA alone.

AB - Fear-related behaviors are prone to relapse following extinction. We tested in humans a compound extinction design ("deepened extinction") shown in animal studies to reduce post-extinction fear recovery. Adult subjects underwent fear conditioning to a visual and an auditory conditioned stimulus (CSA and CSB, respectively) separately paired with an electric shock. The target CS (CSA) was extinguished alone followed by compound presentations of the extinguished CSA and non-extinguished CSB. Recovery of conditioned skin conductance responses to CSA was reduced 24 h after compound extinction, as compared with a group who received an equal number of extinction trials to the CSA alone.

UR - http://www.scopus.com/inward/record.url?scp=84950120309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950120309&partnerID=8YFLogxK

U2 - 10.1101/lm.039479.115

DO - 10.1101/lm.039479.115

M3 - Article

C2 - 26572649

AN - SCOPUS:84950120309

SN - 1072-0502

VL - 22

SP - 589

EP - 593

JO - Learning and Memory

JF - Learning and Memory

IS - 12

ER -

Compound stimulus extinction reduces spontaneous recovery in humans

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this