Comprehensive imaging of cortical networks

Simon Peron; Tsai Wen Chen; Karel Svoboda

doi:10.1016/j.conb.2015.03.016

Comprehensive imaging of cortical networks

Simon Peron, Tsai Wen Chen, Karel Svoboda

Neural Science

Research output: Contribution to journal › Review article › peer-review

Abstract

Neural computations are implemented by activity in spatially distributed neural circuits. Cellular imaging fills a unique niche in linking activity of specific types of neurons to behavior, over spatial scales spanning single neurons to entire brain regions, and temporal scales from milliseconds to months. Imaging may soon make it possible to track activity of all neurons in a brain region, such as a cortical column. We review recent methodological advances that facilitate optical imaging of neuronal populations in vivo, with an emphasis on calcium imaging using protein indicators in mice. We point out areas that are particularly ripe for future developments.

Original language	English (US)
Pages (from-to)	115-123
Number of pages	9
Journal	Current Opinion in Neurobiology
Volume	32
DOIs	https://doi.org/10.1016/j.conb.2015.03.016
State	Published - Jun 1 2015

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.conb.2015.03.016

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abstract = "Neural computations are implemented by activity in spatially distributed neural circuits. Cellular imaging fills a unique niche in linking activity of specific types of neurons to behavior, over spatial scales spanning single neurons to entire brain regions, and temporal scales from milliseconds to months. Imaging may soon make it possible to track activity of all neurons in a brain region, such as a cortical column. We review recent methodological advances that facilitate optical imaging of neuronal populations in vivo, with an emphasis on calcium imaging using protein indicators in mice. We point out areas that are particularly ripe for future developments.",

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AB - Neural computations are implemented by activity in spatially distributed neural circuits. Cellular imaging fills a unique niche in linking activity of specific types of neurons to behavior, over spatial scales spanning single neurons to entire brain regions, and temporal scales from milliseconds to months. Imaging may soon make it possible to track activity of all neurons in a brain region, such as a cortical column. We review recent methodological advances that facilitate optical imaging of neuronal populations in vivo, with an emphasis on calcium imaging using protein indicators in mice. We point out areas that are particularly ripe for future developments.

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Comprehensive imaging of cortical networks

Abstract

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