Compressed sensing sodium MRI of cartilage at 7T: Preliminary study

Guillaume Madelin, Gregory Chang, Ricardo Otazo, Alexej Jerschow, Ravinder R. Regatte

Research output: Contribution to journalArticlepeer-review


Sodium MRI has been shown to be highly specific for glycosaminoglycan (GAG) content in articular cartilage, the loss of which is an early sign of osteoarthritis (OA). Quantitative sodium MRI techniques are therefore under development in order to detect and assess early biochemical degradation of cartilage, but due to low sodium NMR sensitivity and its low concentration, sodium images need long acquisition times (15-25 min) even at high magnetic fields and are typically of low resolution. In this preliminary study, we show that compressed sensing can be applied to reduce the acquisition time by a factor of 2 at 7T without losing sodium quantification accuracy. Alternatively, the nonlinear reconstruction technique can be used to denoise fully-sampled images. We expect to even further reduce this acquisition time by using parallel imaging techniques combined with SNR-improved 3D sequences at 3T and 7T.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalJournal of Magnetic Resonance
StatePublished - Jan 2012


  • Cartilage
  • Compressed sensing
  • Magnetic resonance imaging
  • Osteoarthritis
  • Sodium

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics


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