Computational anatomy to assess longitudinal trajectory of brain growth

G. Gerig, B. Davis, P. Lorenzen, Shun Xu, M. Jomier, J. Piven, S. Joshi

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    This paper addresses the challenging problem of statistics on images by describing average and variability. We describe computational anatomy tools for building 3-D and spatio-temporal 4-D atlases of volumetric image data. The method is based on the previously published concept of unbiased atlas building, calculating the nonlinear average image of a population of images by simultaneous nonlinear deformable registration. Unlike linear averaging, the resulting center average image is sharp and encodes the average structure and geometry of the whole population. Variability is encoded in the set of deformation maps. As a new extension, longitudinal change is assessed by quantifying local deformation between atlases taken at consecutive time points. Morphological differences between groups are analyzed by the same concept but comparing group-specific atlases. Preliminary tests demonstrate that the atlas building shows excellent robustness and a very good convergence, i.e. atlases start to stabilize after 5 images only and do not show significant changes when including more than 10 volumetric images taken from the same population.

    Original languageEnglish (US)
    Title of host publicationProceedings - 3rd International Symposium on 3D Data Processing, Visualization, and Transmission, 3DPVT 2006
    PublisherIEEE Computer Society
    Pages1041-1047
    Number of pages7
    ISBN (Print)0769528252, 9780769528250
    DOIs
    StatePublished - 2006
    Event3rd International Symposium on 3D Data Processing, Visualization, and Transmission, 3DPVT 2006 - Chapel Hill, NC, United States
    Duration: Jun 14 2006Jun 16 2006

    Publication series

    NameProceedings - Third International Symposium on 3D Data Processing, Visualization, and Transmission, 3DPVT 2006

    Other

    Other3rd International Symposium on 3D Data Processing, Visualization, and Transmission, 3DPVT 2006
    CountryUnited States
    CityChapel Hill, NC
    Period6/14/066/16/06

    ASJC Scopus subject areas

    • Computer Graphics and Computer-Aided Design
    • Computer Networks and Communications

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