@article{3472e2ac750c49f18a1ae2160c23513e,
title = "Computational psychiatry and the challenge of schizophrenia",
abstract = "Schizophrenia research is plagued by enormous challenges in integrating and analyzing large datasets and difficulties developing formal theories related to the etiology, pathophysiology, and treatment of this disorder. Computational psychiatry provides a path to enhance analyses of these large and complex datasets and to promote the development and refinement of formal models for features of this disorder. This presentation introduces the reader to the notion of computational psychiatry and describes discovery-oriented and theory-driven applications to schizophrenia involving machine learning, reinforcement learning theory, and biophysically- informed neural circuit models.",
keywords = "Computational neuroscience, Computational psychiatry, Delusions, Machine learning, Medication selection, Schizophrenia, Working memory",
author = "Krystal, {John H.} and Murray, {John D.} and Chekroud, {Adam M.} and Corlett, {Philip R.} and Genevieve Yang and Wang, {Xiao Jing} and Alan Anticevic",
note = "Funding Information: This article was supported by the National Center for Advancing Translational Science grant 1UH2TR000960- 01, the National Institute on Alcohol Abuse and Alcoholism grants P50AA12870 (J.H.K.), the Yale Center for Clinical Investigation grant UL1 RR024139, and the Department of Veterans Affairs through its support for the VA National Center for PTSD (J.H.K.). Additional support came from National Institutes of Health grants DP50D012109-02 (A.A.); the National Alliance for Research on Schizophrenia and Depression Independent Investigator award (A.A.); Blackthorn Therapeutics (A.A.); R01 MH108590 (A.A.); NIMH R01-MH062349 (X-J.W., J.D.M.); and NIMH F30 MH107149 and NIH T32GM 007205 (G.Y.). P.R.C. was funded by NIMH-R01MH067073 an IMHRO/Janssen Rising Star Translational Research Award and CTSA grant number UL1 TR000142 from the National Center for Advancing Translational Science (NCATS), components of the National Institutes of Health (NIH), and NIH roadmap for Medical Research.",
year = "2017",
month = may,
day = "1",
doi = "10.1093/schbul/sbx025",
language = "English (US)",
volume = "43",
pages = "473--475",
journal = "Schizophrenia bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "3",
}