Computational tools for cellular scale biophysics

David B. Stein, Michael J. Shelley

Research output: Contribution to journalReview articlepeer-review


Mathematical models are indispensable for disentangling the interactions through which biological components work together to generate the forces and flows that position, mix, and distribute proteins, nutrients, and organelles within the cell. To illuminate the ever more specific questions studied at the edge of biological inquiry, such models inevitably become more complex. Solving, simulating, and learning from these more realistic models requires the development of new analytic techniques, numerical methods, and scalable software. In this review, we discuss some recent developments in tools for understanding how large numbers of cytoskeletal filaments, driven by molecular motors and interacting with the cytoplasm and other structures in their environment, generate fluid flows, instabilities, and material deformations which help drive crucial cellular processes.

Original languageEnglish (US)
Article number102379
JournalCurrent Opinion in Cell Biology
StatePublished - Aug 2024

ASJC Scopus subject areas

  • Cell Biology


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