Computer-aided interpretation approach for optical tomographic images

Christian D. Klose, Alexander D. Klose, Uwe J. Netz, Alexander K. Scheel, Jürgen Beuthan, Andreas H. Hielscher

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A computer-aided interpretation approach is proposed to detect rheumatic arthritis (RA) in human finger joints using optical tomographic images. The image interpretation method employs a classification algorithm that makes use of a so-called self-organizing mapping scheme to classify fingers as either affected or unaffected by RA. Unlike in previous studies, this allows for combining multiple image features, such as minimum and maximum values of the absorption coefficient for identifying affected and not affected joints. Classification performances obtained by the proposed method were evaluated in terms of sensitivity, specificity, Youden index, and mutual information. Different methods (i.e., clinical diagnostics, ultrasound imaging, magnet resonance imaging, and inspection of optical tomographic images), were used to produce ground truth benchmarks to determine the performance of image interpretations. Using data from 100 finger joints, findings suggest that some parameter combinations lead to higher sensitivities, while others to higher specificities when compared to single parameter classifications employed in previous studies. Maximum performances are reached when combining the minimum/maximum ratio of the absorption coefficient and image variance. In this case, sensitivities and specificities over 0.9 can be achieved. These values are much higher than values obtained when only single parameter classifications were used, where sensitivities and specificities remained well below 0.8.

    Original languageEnglish (US)
    Article number066020
    JournalJournal of biomedical optics
    Volume15
    Issue number6
    DOIs
    StatePublished - Nov 2010

    Keywords

    • arthritis
    • classification
    • computer-aided diagnostics
    • image feature extraction
    • optical tomography

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Atomic and Molecular Physics, and Optics
    • Biomedical Engineering

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