Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry