Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305

Erica M. Wilson, Dirk Trauner

Research output: Contribution to journalArticlepeer-review

Abstract

Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.

Original languageEnglish (US)
Pages (from-to)1327-1329
Number of pages3
JournalOrganic Letters
Volume9
Issue number7
DOIs
StatePublished - Mar 29 2007

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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