Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305

Erica M. Wilson; Dirk Trauner

doi:10.1021/ol070173u

Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305

Erica M. Wilson, Dirk Trauner

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.

Original language	English (US)
Pages (from-to)	1327-1329
Number of pages	3
Journal	Organic Letters
Volume	9
Issue number	7
DOIs	https://doi.org/10.1021/ol070173u
State	Published - Mar 29 2007

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol070173u

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title = "Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305",

abstract = "Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.",

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AB - Figure presented A highly convergent, enantioselective synthesis of (+)-Sch 642305 is presented, which features a Mukaiyama-Michael addition followed by allylation to establish the syn-anti relationship of the three contiguous stereocenters. The 10-membered macrolactone was formed through ring-closing metathesis.

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Concise synthesis of the bacterial DNA primase inhibitor (+)-Sch 642305

Abstract

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