Concise total synthesis of (-)-frondosin B using a novel palladium-catalyzed cyclization

Chambers C. Hughes, Dirk Trauner

Research output: Contribution to journalArticlepeer-review


Sidestepping stereochemical inversion: In an expedient, asymmetric total synthesis of (-)-frondosin B a novel palladium-catalyzed cyclization establishes the tetracyclic skeleton (see scheme). The absolute stereochemistry of naturally occurring marine metabolite (+)-frondosin B, an interleukin-8 inhibitor, has been reassigned. Tf = trifluoromethanesulfonyl.

Original languageEnglish (US)
Pages (from-to)1569-1572
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number9
StatePublished - May 3 2002


  • Cyclization
  • Natural products
  • Palladium
  • Polycycles
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


Dive into the research topics of 'Concise total synthesis of (-)-frondosin B using a novel palladium-catalyzed cyclization'. Together they form a unique fingerprint.

Cite this