Abstract
Sidestepping stereochemical inversion: In an expedient, asymmetric total synthesis of (-)-frondosin B a novel palladium-catalyzed cyclization establishes the tetracyclic skeleton (see scheme). The absolute stereochemistry of naturally occurring marine metabolite (+)-frondosin B, an interleukin-8 inhibitor, has been reassigned. Tf = trifluoromethanesulfonyl.
Original language | English (US) |
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Pages (from-to) | 1569-1572 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 41 |
Issue number | 9 |
DOIs | |
State | Published - May 3 2002 |
Keywords
- Cyclization
- Natural products
- Palladium
- Polycycles
- Total synthesis
ASJC Scopus subject areas
- Catalysis
- General Chemistry