Condensin action and compaction

Matthew Robert Paul, Andreas Hochwagen, Sevinç Ercan

Research output: Contribution to journalReview article

Abstract

Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

Original languageEnglish (US)
Pages (from-to)407-415
Number of pages9
JournalCurrent Genetics
Volume65
Issue number2
DOIs
StatePublished - Apr 5 2019

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Keywords

  • Chromosome interactions
  • Chromosome segregation
  • Clustering
  • Condensin
  • Genome organization
  • SMCcomplexes
  • TADs
  • Transcription
  • gene expression
  • rDNA
  • tRNA

ASJC Scopus subject areas

  • Genetics

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