Condensin action and compaction

Matthew Robert Paul; Andreas Hochwagen; Sevinç Ercan

doi:10.1007/s00294-018-0899-4

Condensin action and compaction

Matthew Robert Paul, Andreas Hochwagen, Sevinç Ercan

Biology and Genomics

Research output: Contribution to journal › Review article › peer-review

Abstract

Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

Original language	English (US)
Pages (from-to)	407-415
Number of pages	9
Journal	Current Genetics
Volume	65
Issue number	2
DOIs	https://doi.org/10.1007/s00294-018-0899-4
State	Published - Apr 5 2019

Keywords

Chromosome interactions
Chromosome segregation
Clustering
Condensin
Genome organization
SMCcomplexes
TADs
Transcription
gene expression
rDNA
tRNA

ASJC Scopus subject areas

Genetics

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10.1007/s00294-018-0899-4

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title = "Condensin action and compaction",

abstract = "Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.",

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AU - Ercan, Sevinç

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AB - Condensin is a multi-subunit protein complex that belongs to the family of structural maintenance of chromosomes (SMC) complexes. Condensins regulate chromosome structure in a wide range of processes including chromosome segregation, gene regulation, DNA repair and recombination. Recent research defined the structural features and molecular activities of condensins, but it is unclear how these activities are connected to the multitude of phenotypes and functions attributed to condensins. In this review, we briefly discuss the different molecular mechanisms by which condensins may regulate global chromosome compaction, organization of topologically associated domains, clustering of specific loci such as tRNA genes, rDNA segregation, and gene regulation.

KW - Chromosome interactions

KW - Chromosome segregation

KW - Clustering

KW - Condensin

KW - Genome organization

KW - SMCcomplexes

KW - TADs

KW - Transcription

KW - gene expression

KW - rDNA

KW - tRNA

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Condensin action and compaction

Abstract

Keywords

ASJC Scopus subject areas

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