Abstract
An important aspect of the immunological response to silicon implants is the interaction between low-molecular-weight silicones, like cyclic silicones, and protein molecules. Fibrinogen and fibronectin were incubated with the cyclic silicone octamethylcyclotetrasiloxane (D4) with stirring under normal conditions for up to 8 hours. The effect of D4 on both proteins were investigated by fluorescence and circular dichroism spectroscopy. The study indicated that cyclic silicone induces conformational change and denaturation in fibrinogen and fibronectin, common proteins in human plasma and tissue.
Original language | English (US) |
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Number of pages | 1 |
State | Published - 1996 |
Event | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can Duration: May 29 1996 → Jun 2 1996 |
Other
Other | Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) |
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City | Toronto, Can |
Period | 5/29/96 → 6/2/96 |
ASJC Scopus subject areas
- General Materials Science