Conformational change and denaturation of proteins by cyclic silicone

L. Sun, H. Alexander, N. Lattarulo, N. C. Blumenthal, J. L. Ricci, G. Chen

Research output: Contribution to conferencePaper

Abstract

An important aspect of the immunological response to silicon implants is the interaction between low-molecular-weight silicones, like cyclic silicones, and protein molecules. Fibrinogen and fibronectin were incubated with the cyclic silicone octamethylcyclotetrasiloxane (D4) with stirring under normal conditions for up to 8 hours. The effect of D4 on both proteins were investigated by fluorescence and circular dichroism spectroscopy. The study indicated that cyclic silicone induces conformational change and denaturation in fibrinogen and fibronectin, common proteins in human plasma and tissue.

Original languageEnglish (US)
Number of pages1
StatePublished - 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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    Sun, L., Alexander, H., Lattarulo, N., Blumenthal, N. C., Ricci, J. L., & Chen, G. (1996). Conformational change and denaturation of proteins by cyclic silicone. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .