Conformational changes of aspartate induced by high salt concentrations

Gennaro Esposito, Antonio Donesi, Piero A. Temussi

Research output: Contribution to journalArticlepeer-review

Abstract

The conformational changes of aspartate induced by increasing ionic strength were investigated by means of NMR spectroscopy. The effects of Li, Na, K and Cs chlorides in basic solutions show a relative stabilization of the two conformers with gauche carboxylates at the expense of the anti conformer. A significant quantitative difference was found between Na+ and K+. The changes observed in neutral solutions, although larger than those in basic solutions, are dominated by the zwitterion interaction.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalAdvances in Molecular Relaxation and Interaction Processes
Volume24
Issue number1
DOIs
StatePublished - Sep 1982

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