@article{08aa194e323a4c37b92e9949306edbdc,
title = "Conformational control of propeller-like chirality in Zn(II) complexes: Tightly balanced steric bias",
abstract = "The conformational behavior of a series of chiral tripodal ligand-Zn(II) complexes was examined. The ligands adopt propeller-like conformations upon complexation of trigonal bipyramidal metal ions such as Zn(II), with the chirality of the propeller determined by the absolute configuration of a single chiral center in one of the tripod arms. Surprisingly, increasing the size of the substituent in the chiral arm did not improve the geometrical definition of the complexes, as indicated by the circular dichroism spectra of the complexes.",
keywords = "Circular dichroism, Conformation, Molecular devices, Stereoisomerism",
author = "Chiu, {Yu Hung} and {Dos Santos}, Osvaldo and Canary, {James W.}",
note = "Funding Information: Spectroscopic studies: UV-VIS spectra of the compounds were acquired with I0 ~M solution in acetonitrile on a Perkin Elmer Lambda 5 spectrophotometer. CD spectra were obtained with 0.3 mM solution in acetonitrile on an Aviv 62DS spectrometer. The zinc complexes were generated by adding I.I eq. of zinc perchlorate in acetonitrile to the free ligands in acetonitrile solution. Previous work demonstrated that spectra obtained in this way were identical to those obtained from preformed, fully characterized zinc complexes. 5 All ligands and complexes used to measure the spectra shown in Fig. 6 were >95% ee except for 8 which was 81% Acknowledgment. We thank the National Institutes of Health (GM 49170) for support of this research. We are grateful to Jesus Castagnetto for help with calculations. El, FAB, and high-resointion mass spectra were obtained at the Michigan State University Mass Spectrometry Facility (supported in part by grant DRR-00480, from the Biotechnology Research Technology Program, NCRS, NIH). We are grateful to Professor Nina Berova for helpful discussions. We thank Chiral Technologies, Inc. for determination of the enantiomeric purity of 5 and 6.",
year = "1999",
month = oct,
day = "8",
doi = "10.1016/S0040-4020(99)00713-9",
language = "English (US)",
volume = "55",
pages = "12069--12078",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "41",
}