Consequences of cooperativity in racemizing supramolecular systems

Seda Cantekin, Huub M.M. Ten Eikelder, Albert J. Markvoort, Martijn A.J. Veld, Peter A. Korevaar, Mark M. Green, Anja R.A. Palmans, E. W. Meijer

Research output: Contribution to journalArticlepeer-review


Saluting the sergeant: Phg-BTA (see scheme) cooperatively self-assembles into helical aggregates and shows unprecedented racemization behavior in the presence of base. In thermodynamically controlled conditions, the addition of a small amount of chiral auxiliary to this mixture results in a deracemization reaction and a final enantiomeric excess of 32 %. A theoretical model is presented to understand in detail the results obtained.

Original languageEnglish (US)
Pages (from-to)6426-6431
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number26
StatePublished - Jun 25 2012


  • deracemization
  • enantiomeric excess
  • nonlinear effects
  • self-assembly
  • supramolecular chemistry

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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