Consumption of sugary foods and drinks and risk of endometrial cancer

Melony G. King, Urmila Chandran, Sara H. Olson, Kitaw Demissie, Shou En Lu, Niyati Parekh, Elisa V. Bandera

Research output: Contribution to journalArticlepeer-review


Consumption of foods high in sugar promotes insulin production, which has been linked to endometrial carcinogenesis. We evaluated the impact of dietary intake of sugary foods and beverages, as well as added sugar and total sugar on endometrial cancer risk in a population-based case-control study, including 424 cases and 398 controls. Participants completed an interview and food frequency questionnaire, and provided self-recorded waist and hip measurements. Women in the highest quartile of added sugar intake had significantly increased endometrial cancer risk (OR = 1.84, 95 % CI 1.16-2.92). Among women with waist-to-hip ratio ≥0.85, risk was significantly higher for the highest versus lowest tertile of added sugar intakes (OR = 2.50, 95 % CI 1.38-4.52). The association with added sugar also became stronger when analyses were restricted to never users of hormone replacement therapy (OR = 2.03; 95 % CI 1.27-3.26, for highest versus lowest tertile). There was little evidence of effect modification by body mass index or physical activity. Given the high prevalence of intake of sugary foods and drinks in Western populations, additional research is warranted to confirm our findings on endometrial cancer.

Original languageEnglish (US)
Pages (from-to)1427-1436
Number of pages10
JournalCancer Causes and Control
Issue number7
StatePublished - Jul 2013


  • Added sugars
  • Diet
  • Endometrial neoplasms
  • Sugar
  • Sugary drinks
  • Sugary foods

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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