Contrasting short- and long-term effects of weight loss on lipoprotein levels

M. J. Follick, David Abrams, T. W. Smith, L. O. Henderson, P. N. Herbert

Research output: Contribution to journalArticlepeer-review


The short- and long-term effects of weight loss on high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels were examined in 42 women who completed a 14-session behavioral weight-loss program. Lipid values were determined from samples taken before treatment, after treatment, and at six-month follow-up. There were significant changes in plasma lipid levels, but the short- and long-term effects differed. Both total and LDL cholesterol levels decreased during treatment and remained lower at follow-up. However, HDL cholesterol level and the HDL/LDL ratio did not change during treatment but increased significantly above pretreatment levels at follow-up. Furthermore, long-term changes in lipoprotein levels were significantly correlated with changes in the body-mass index even after correction for initial values. These results show that weight loss can, in the long term, have a potentially beneficial impact on lipoprotein levels in women.

Original languageEnglish (US)
Pages (from-to)1571-1574
Number of pages4
JournalArchives of Internal Medicine
Issue number8
StatePublished - 1984

ASJC Scopus subject areas

  • Internal Medicine


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