TY - JOUR
T1 - Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels
AU - Keely, Stephen J.
AU - Urso, Andreacarola
AU - Ilyaskin, Alexandr V.
AU - Korbmacher, Christoph
AU - Bunnett, Nigel W.
AU - Poole, Daniel P.
AU - Carbone, Simona E.
N1 - Funding Information:
N. W. Bunnett is a founding scientist of Endosome Therapeutics Inc. Research in the laboratories of N. W. Bunnett, D. P. Poole, and S. E. Carbone is funded in part by Takeda Pharmaceuticals. None of the other authors has any conflicts of interest, financial or otherwise, to disclose.
Funding Information:
S. E. Carbone is supported by an Australian Research Council DECRA Fellow Grant DE200100825. Research in the author’s laboratories is supported by National Health and Medical Research Council Australia 1083480 (to D. P. Poole), National Institutes of Health Grants NS102722, DE026806, DE029951, DK118971 (to N. W. Bunnett), Department of Defense Grant W81XWH1810431 (to N. W. Bunnett), the ELAN program of the Interdisciplinary Center for Clinical Research, Erlangen (IZKF) Grant 17-08-01-1-Ilyaskin/P015 (to A.V. Ilyaskin), and by Science Foundation Ireland Grant No. 16/ IA/4445 (to S. J. Keely).
Publisher Copyright:
Copyright © 2022 the American Physiological Society.
PY - 2022/2
Y1 - 2022/2
N2 - Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades, significant advances in identifying and characterizing the receptors, transporters, and ion channels targeted by BAs have led to exciting new insights into the molecular mechanisms involved in these processes. Our appreciation of BAs, their receptors, and BA-modulated ion channels as potential targets for the development of new approaches to treat intestinal motility and transport disorders is increasing. In the current review, we aim to summarize recent advances in our knowledge of the different BA receptors and BA-modulated ion channels present in the gastrointestinal system. We discuss how they regulate motility and epithelial transport, their roles in pathogenesis, and their therapeutic potential in a range of gastrointestinal diseases.
AB - Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades, significant advances in identifying and characterizing the receptors, transporters, and ion channels targeted by BAs have led to exciting new insights into the molecular mechanisms involved in these processes. Our appreciation of BAs, their receptors, and BA-modulated ion channels as potential targets for the development of new approaches to treat intestinal motility and transport disorders is increasing. In the current review, we aim to summarize recent advances in our knowledge of the different BA receptors and BA-modulated ion channels present in the gastrointestinal system. We discuss how they regulate motility and epithelial transport, their roles in pathogenesis, and their therapeutic potential in a range of gastrointestinal diseases.
KW - Bile acid
KW - FXR
KW - Motility
KW - Secretion
KW - TGR5
KW - Gastrointestinal Tract/drug effects
KW - Humans
KW - Ion Channels/agonists
KW - Receptors, Calcitriol/drug effects
KW - Sodium Channels/drug effects
KW - Liver/drug effects
KW - Bile Acids and Salts/metabolism
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U2 - 10.1152/ajpgi.00125.2021
DO - 10.1152/ajpgi.00125.2021
M3 - Review article
C2 - 34755536
AN - SCOPUS:85123812507
VL - 322
SP - G201
JO - American Journal of Physiology - Gastrointestinal and Liver Physiology
JF - American Journal of Physiology - Gastrointestinal and Liver Physiology
SN - 0193-1857
IS - 2
ER -