Controlled and Uncontrolled Stochastic Norton-Simon-Massagué Tumor Growth Models

Zehor Belkhatir, Michele Pavon, James C. Mathews, Maryam Pouryahya, Joseph O. Deasy, Larry Norton, Allen R. Tannenbaum

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Tumorigenesis is a complex process that is heterogeneous and affected by numerous sources of variability. This study presents a stochastic extension of a biologically grounded tumor growth model, referred to as the Norton-Simon-Massague (NSM) tumor growth model. We first studý the uncontrolled version of the model where the effect of chemotherapeutic drug agent is absent. Conditions on the model's parameters are derived to guarantee the positivity of the tumor volume and hence the validity of the proposed stochastic NSM model. To calibrate the proposed model we utilize a maximum likelihood-based estimation algorithm and population mixed-effect modeling formulation. The algorithm is tested by fitting previously published tumor volume mice data. Then, we study the controlled version of the model which includes the effect of chemotherapy treatment. A closed-loop control strategy that relies on model predictive control (MPC) combined with extended Kalman filter (EKF) is proposed to solve an optimal cancer therapy planning problem.

Original languageEnglish (US)
Title of host publication2019 IEEE 58th Conference on Decision and Control, CDC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages6
ISBN (Electronic)9781728113982
StatePublished - Dec 2019
Event58th IEEE Conference on Decision and Control, CDC 2019 - Nice, France
Duration: Dec 11 2019Dec 13 2019

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0743-1546
ISSN (Electronic)2576-2370


Conference58th IEEE Conference on Decision and Control, CDC 2019

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Modeling and Simulation
  • Control and Optimization


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