Controlled release strategies in tissue engineering

Jeffrey J. Rice; Mikaël M. Martino; Sharan Bobbala; Evan A. Scott; Jeffrey A. Hubbell

doi:10.1016/B978-0-12-824459-3.00012-3

Controlled release strategies in tissue engineering

Jeffrey J. Rice, Mikaël M. Martino, Sharan Bobbala, Evan A. Scott, Jeffrey A. Hubbell

Chemical and Biomolecular Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The controlled release of biological factors is an essential component of the many aspects of tissue engineering. The primary objective of the controlled release of cell signaling molecules is to present desired biological factors to the targeted cells at an optimal concentration for an optimal duration of time. Over the previous decades, engineers have designed a variety of systems to precisely control the release rates of various biomolecules for many tissue engineering applications. This chapter describes the prominent methods that have been used to entrap bioactive factors within biomaterials to control the presentation and delivery of these factors.

Original language	English (US)
Title of host publication	Tissue Engineering, Third Edition
Publisher	Elsevier
Pages	387-430
Number of pages	44
ISBN (Electronic)	9780128244593
ISBN (Print)	9780323851343
DOIs	https://doi.org/10.1016/B978-0-12-824459-3.00012-3
State	Published - Jan 1 2022

Keywords

Biomaterials
Controlled release
Extracellular matrix
Growth factors
Hydrogels

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology
General Medicine

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10.1016/B978-0-12-824459-3.00012-3

Cite this

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AU - Martino, Mikaël M.

AU - Bobbala, Sharan

AU - Scott, Evan A.

AU - Hubbell, Jeffrey A.

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AB - The controlled release of biological factors is an essential component of the many aspects of tissue engineering. The primary objective of the controlled release of cell signaling molecules is to present desired biological factors to the targeted cells at an optimal concentration for an optimal duration of time. Over the previous decades, engineers have designed a variety of systems to precisely control the release rates of various biomolecules for many tissue engineering applications. This chapter describes the prominent methods that have been used to entrap bioactive factors within biomaterials to control the presentation and delivery of these factors.

KW - Biomaterials

KW - Controlled release

KW - Extracellular matrix

KW - Growth factors

KW - Hydrogels

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BT - Tissue Engineering, Third Edition

PB - Elsevier

ER -

Controlled release strategies in tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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