Controlling curvature in a family of oligoamide α-helix mimetics

Ishu Saraogi, Christopher D. Incarvito, Andrew D. Hamilton

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Catching up with the curve! The natural curvature found in a majority of a helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of a helices.

Original languageEnglish (US)
Pages (from-to)9691-9694
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number50
DOIs
StatePublished - Dec 1 2008

Keywords

  • Curvature
  • Helical structures
  • Hydrogen bonds
  • Oligoamides
  • Proteomimetics

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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