Controlling curvature in a family of oligoamide α-helix mimetics

Ishu Saraogi; Christopher D. Incarvito; Andrew D. Hamilton

doi:10.1002/anie.200803778

Controlling curvature in a family of oligoamide α-helix mimetics

Ishu Saraogi, Christopher D. Incarvito, Andrew D. Hamilton

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

(Figure Presented) Catching up with the curve! The natural curvature found in a majority of a helices has been mimicked in small synthetic oligoamide scaffolds. Differences in hydrogen-bonding patterns in these scaffolds lead to mimetics with varying degrees of curvature in the backbone. This adds another parameter to the structural and functional mimicry of a helices.

Original language	English (US)
Pages (from-to)	9691-9694
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	50
DOIs	https://doi.org/10.1002/anie.200803778
State	Published - Dec 1 2008

Keywords

Curvature
Helical structures
Hydrogen bonds
Oligoamides
Proteomimetics

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200803778

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Controlling curvature in a family of oligoamide α-helix mimetics

Abstract

Keywords

ASJC Scopus subject areas

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