@inproceedings{fa197abb35a047758bb1bb117840f559,
title = "Controlling the body orientation of C. elegans by exploiting its proprioception in a microfluidic confinement for body wall muscle imaging",
abstract = "Controlling the body orientation of C. elegans for imaging on widely used agarose pad is a challenging task requiring laborious manual manipulation. Here, we report a microfluidic device to control its body orientation for fluorescence imaging of its body wall muscles. Our device takes advantage of the innate proprioception of the worm to rotate its body in a channel with an aspect ratio over 1 in order to obtain maximum free space for its body undulation motion. Exploiting this feature, we observed a significant decrease in the mitochondrial fluorescence intensity under hyperglycemic conditions not discernible with the agarose pad.",
keywords = "Body imaging, Body wall muscle, C. elegans, Hyperglycemia, Proprioception",
author = "Samuel Sofela and Sarah Sahloul and Sukanta Bhattacharjee and Song, {Yong Ak}",
note = "Publisher Copyright: {\textcopyright} 2020 CBMS-0001; 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
year = "2020",
language = "English (US)",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "903--904",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}